@article{Chen2022, 
author = {Tao Chen and Lichao Su and Lisen Lin and Xiaoguang Ge and Feicheng Bai and Meng Niu and Chenlu Wang and Jibin Song and Shaolei Guo and Huanghao Yang},
title = {Mesoporous radiosensitized nanoprobe for enhanced NIR-II photoacoustic imaging-guided accurate radio-chemotherapy},
year = {2022},
journal = {Nano Research},
volume = {15},
number = {5},
pages = {4154-4163},
keywords = {radiotherapy, second near infrared window (NIR-II), photoacoustic imaging, tumor hypoxia, photocatalysis},
url = {https://www.sciopen.com/article/10.1007/s12274-021-3997-4},
doi = {10.1007/s12274-021-3997-4},
abstract = {Oxygen deficiency is a major obstacle to hypoxic-related cancer theranostics, and developing the oxygen production nanoplatforms received the widespread attention. However, it is remaining a challenge to structure a nanoplatform with hypoxia alleviation effect and imaging-guided cancer radiotherapy. Herein, we present a novel theranostics nanoplatform (Au NPs/UCNPs/WO3@C) comprising of tungsten trioxide (WO3) that loaded gold nanoparticles (Au NPs) and up-conversion nanoparticles (UCNPs) for improved photoacoustic (PA) imaging performance in the second near infrared window (NIR-II, 900–1,700 nm). Au NPs/UCNPs/WO3@C exhibited superior oxygen-generation effect and doxorubicin loading capacity, thus serving as an efficient radiosensitizer for radio-chemo anti-cancer therapy. Importantly, the accumulated Au NPs/UCNPs/WO3@C in the tumor region led to the increased NIR-II PA imaging signal and the blood oxygen saturation signal, which could enhance radiation sensitivity and accurately guiding cancer radiotherapy to reduce side effects on normal tissues. This study with proof-of-concept confirmed the multifaceted characteristics and encouraging potential of biomimetic Au NPs/UCNPs/WO3@C for NIR-II PA imaging-guided tumor therapeutics.}
}