@article{Yang2016, 
author = {Yu Yang and Jingjing Liu and Xiaoqi Sun and Liangzhu Feng and Wenwen Zhu and Zhuang Liu and Meiwan Chen},
title = {Near-infrared light-activated cancer cell targeting and drug delivery with aptamer-modified nanostructures},
year = {2016},
journal = {Nano Research},
volume = {9},
number = {1},
pages = {139-148},
keywords = {drug delivery, gold nanorods, aptamer, single-walled carbon nanotubes, near-infrared (NIR)-activable},
url = {https://www.sciopen.com/article/10.1007/s12274-015-0898-4},
doi = {10.1007/s12274-015-0898-4},
abstract = {Stimuli-activated targeted delivery systems for highly accurate treatment of tumors have received considerable attention in recent years. Herein, we reveal a light-activable cancer-targeting strategy that uses a complementary DNA sequence to hybridize and mask sgc8 aptamers conjugated onto photothermal agents such as gold nanorods or single-walled carbon nanotubes (SWNTs). Upon exposure to near-infrared (NIR) laser, localized photothermal heating of the surface of those nano-agents results in dehybridization of the double-stranded DNA and uncaging of the aptamer sequence to allow specific cancer-cell targeting. Utilizing doxorubicin-loaded SWNTs as a model system, targeted drug delivery to cancer cells activated by NIR light was achieved. This work demonstrates the concept of NIR-activable tumor-targeting delivery systems with controllable cancer-cell binding to potentially enable highly specific and efficient cancer therapy.}
}