@article{Pan2021, 
author = {Lu Pan and Ya-Nan Ou and Lin Tan and Lan Tan and Jin-Tai Yu},
title = {Cerebrospinal fluid heart fatty acid-binding protein as a predictive biomarker of neurodegeneration in Alzheimer’s disease},
year = {2021},
journal = {Brain Science Advances},
volume = {7},
number = {1},
pages = {44-55},
keywords = {Alzheimer’s disease, heart fatty acid-binding protein (HFABP), cerebrospinal fluid, biomarker, neurodegeneration},
url = {https://www.sciopen.com/article/10.26599/BSA.2021.9050003},
doi = {10.26599/BSA.2021.9050003},
abstract = {Objective:This study aims to investigate whether the heart fatty acid-binding protein (HFABP) in the cerebrospinal fluid (CSF) was a potential predictive biomarker for Alzheimer’s disease (AD).Methods:We evaluated the associations of CSF HFABP levels with core biomarkers, cognition, and brain structure in a sample population (n = 302) from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) database. Multiple linear regression and mixed-effects models were employed in the analyses. AD progression was assessed using the Kaplan–Meier survival analysis.Results:CSF HFABP was higher in patients with mild cognitive impairment and AD than the normal controls (p < 0.001) and was particularly higher in those with amyloid-β (Aβ) pathologic features. CSF HFABP was associated with higher baseline CSF t-tau (p < 0.001), CSF p-tau (p < 0.001), and CSF t-tau/Aβ42 and CSF p-tau/Aβ42 (p < 0.01). Moreover, CSF HFABP was found to play predictive roles in hippocampal atrophy (p < 0.01), cognitive decline (p < 0.05), and the risk of AD (p < 0.001).Conclusion:Our findings suggest that CSF HFABP can be a predictive biomarker of AD.}
}