@article{Cheng2021, 
author = {Zhijian Cheng and Rui Wang and Kai Cao and Guoyu Wang and Jie Qin and Haopeng Li and Jiaxi Li and Dong Wang and Xijing He},
title = {Ten years of clinical observation of olfactory ensheathing cell transplantation in patients with spinal cord injury},
year = {2021},
journal = {Journal of Neurorestoratology},
volume = {9},
number = {2},
pages = {106-116},
keywords = {spinal cord injury, olfactory ensheathing cells, cell transplantation, clinical observation, retrospective analysis},
url = {https://www.sciopen.com/article/10.26599/JNR.2021.9040009},
doi = {10.26599/JNR.2021.9040009},
abstract = {Objective:To evaluate the long-term curative efficacy and safety of olfactory ensheathing cell (OEC) transplantation by 10 years of follow-up investigation.Methods:A follow-up observation was done on 13 patients with allograft olfactory bulb-derived OEC transplantation from September 2005 to September 2007 at the Second Affiliated Hospital of Xi’an Jiaotong University. After cell purification, amplification, and identification, a 2 × 107/mL cell suspension was prepared for transplantation. In the posterior horn of the spinal cord 0.5 cm distal and proximal to the spinal cord injury zone, 4 needle points were selected to avoid the blood vessels. The needle depth was 3 mm, and the injection volume per point was 10 μL. Postoperatively and at 1 week, 4 weeks, 12 weeks, 24 weeks, 1 year, 3 years, 5 years, and 10 years after the surgery, the patient’s American Spinal Injury Association (ASIA) score, adverse reactions, and other minor observations were assessed.Results:All the patients did not have serious complications. No gliomas or other new organisms formed during the 10-year observation period. Eight of 13 patients had improvement in sensory function, and 5 patients showed improvement in motor function. The ASIA acupuncture, light touch, and exercise scores improved significantly 1 year after the surgery, and this improvement continued until the 10-year follow-up period. Three of 13 patients had improvement in defecation and urination, and 1 patient had improved neuralgia after spinal cord injury.Conclusion:OEC transplantation is safe and effective in treating spinal cord injury. The observation period of OEC transplantation is 1 to 3 years.}
}