@article{Chen2020, 
author = {Tao Chen and Lichao Su and Xiaoguang Ge and Wenmin Zhang and Qingqing Li and Xuan Zhang and Jiamin Ye and Lisen Lin and Jibin Song and Huanghao Yang},
title = {Dual activated NIR-II fluorescence and photoacoustic imaging-guided cancer chemo-radiotherapy using hybrid plasmonic-fluorescent assemblies},
year = {2020},
journal = {Nano Research},
volume = {13},
number = {12},
pages = {3268-3277},
keywords = {radiotherapy, second near-infrared window (NIR-II), fluorescence imaging, photoacoustic imaging, plasmonic gold nanovesicle},
url = {https://www.sciopen.com/article/10.1007/s12274-020-3000-9},
doi = {10.1007/s12274-020-3000-9},
abstract = {Multimodal imaging in the second near-infrared window (NIR-II) guided cancer therapy is a highly precise and efficient cancer theranostic strategy. However, it is still a challenge to develop activated NIR-II optical imaging and therapy agents. In this study, we develop a pH-responsive hybrid plasmonic-fluorescent vesicle by self-assembly of amphiphilic plasmonic nanogapped gold nanorod (AuNNR) and fluorescent down-conversion nanoparticles (DCNP) (AuNNR-DCNP Ve), showing remarkable and activated NIR-II fluorescence (FL)/NIR-II photoacoustic (PA) imaging performances. The hybrid vesicle also exhibited superior loading capacity of doxorubicin as a superior drug carrier and efficient radiosensitizer for X-ray-induced radiotherapy. Interestingly, the accumulated hybrid AuNNR-DCNP Ve in the tumor resulted in a recovery of NIR-II FL imaging signal and a variation in NIR-II PA imaging signal. Dual activated NIR-II PA and FL imaging of the hybrid vesicle could trace drug release and precisely guided cancer radiotherapy to ultimately reduce the side effects to healthy tissue.}
}