@article{Jia2020, 
author = {Yanpeng Jia and Yang Song and Ying Qu and Jinrong Peng and Kun Shi and Dan Du and He Li and Yuehe Lin and Zhiyong Qian},
title = {Mesoporous PtPd nanoparticles for ligand-mediated and imaging-guided chemo-photothermal therapy of breast cancer},
year = {2020},
journal = {Nano Research},
volume = {13},
number = {6},
pages = {1739-1748},
keywords = {porous structure, inorganic nanoparticles, photoacoustic imaging, photothermal therapy, chemotherapy},
url = {https://www.sciopen.com/article/10.1007/s12274-020-2800-2},
doi = {10.1007/s12274-020-2800-2},
abstract = {The synergistic therapy of chemotherapy and photothermal therapy (PTT) has been reported as a promising antitumor strategy. To achieve effective combination therapy, developing more suitable candidate nanomaterials with optimal photothermal property and high chemical drug loading capacity is very necessary. Herein, a bimetallic PtPd nanoparticle was synthesized with the merits of excellent photothermal effect and mesoporous structure for doxorubicin (DOX) loading. We further designed PtPd-ethylene glycol (PEG)-folic acid (FA)-doxorubicin (DOX) nanoparticle for chemo-photothermal therapy of MCF-7 tumor with folic acid engineering to achieve active targeting. Moreover, excellent photoacoustic (PA) imaging of PtPd-PEG-FA-DOX nanoparticles facilitated the precise in vivo tracking and further evaluation of nanoparticles’ targeting effect. The in vitro and in vivo results both demonstrated PtPd-PEG-FA-DOX nanoparticles serve as a safe and promising system for effective treatment of MCF-7 tumor.}
}