@article{Song2020, 
author = {Wentao Song and Yiming Wang and Bing Wang and Yingfang Yao and Wenguang Wang and Jinhui Wu and Qing Shen and Wenjun Luo and Zhigang Zou},
title = {Super stable CsPbBr3@SiO2 tumor imaging reagent by stress-response encapsulation},
year = {2020},
journal = {Nano Research},
volume = {13},
number = {3},
pages = {795-801},
keywords = {CsPbBr3 nanocrystals, stress response encapsulation, cancer diagnose},
url = {https://www.sciopen.com/article/10.1007/s12274-020-2697-9},
doi = {10.1007/s12274-020-2697-9},
abstract = {Great photoelectric properties can herald the high potentials of CsPbBr3 nanocrystals (NCs) to function as the fluorescent probes for early tumor diagnosis. However, the intrinsic water vulnerability of CsPbBr3 NCs highly restricts their biomedical applications. To conquer this challenge, we herein introduce a nature inspired "stress-response" method to tightly encapsulate CsPbBr3 into SiO2 nano-shells that can dramatically improve the water stability of CsPbBr3@SiO2 nanoparticles for over 48 h. We further highlighted the advantageous features of CsPbBr3@SiO2 by using them as the fluorescent probes for CT26 tumor cell imaging with their high water stability, biocompatibility, and low cytotoxicity. Our work for the first time exhibited the potential of lead halide perovskite NCs for tumor diagnosis, and can highly anticipate the further in vivo biomedical applications that light up live cells.}
}