@article{Zhang2020, 
author = {Amin Zhang and Qian Zhang and Gabriel Alfranca and Shaojun Pan and Zhicheng Huang and Jin Cheng and Qiang Ma and Jie Song and Yunxiang Pan and Jian Ni and Lijun Ma and Daxiang Cui},
title = {GSH-triggered sequential catalysis for tumor imaging and eradication based on star-like Au/Pt enzyme carrier system},
year = {2020},
journal = {Nano Research},
volume = {13},
number = {1},
pages = {160-172},
keywords = {peroxidase, Au/Pt star, GSH-responsive, GOx, sequential nanocatalyst, cancer starving-like therapy, enzyme oxidative therapy, photo-thermal therapy & photodynamic therapy (PTT&PDT)},
url = {https://www.sciopen.com/article/10.1007/s12274-019-2591-5},
doi = {10.1007/s12274-019-2591-5},
abstract = {Distinctively different metabolism between tumor cells and normal cells endows tumor tissues unique microenvironment. In this regard, we have successfully prepared a sequential catalytic platform based on Au/Pt star for tumor theragnostic. The multifunctional probes consisted of a gold/platinum star-shaped core (Au/Pt star) conjugated with a GSH-sensitive disulfide bond (S-S), a targeting ligand (rHSA-FA), a near-infrared fluorophore (IR780) and glucose oxidase (GOx). When systemically administered in a xenografted murine model, the probes specifically targeted the tumor sites. As the disulfide linker was cleaved by intracellular GSH, the IR780 molecules could be released for photo-thermal therapy & photodynamic therapy (PTT&PDT) and imaging. Subsequently, the Pt nanolayer of the Au/Pt star and the GOx formed a sequential catalytic system: GOx effectively catalyzed intracellular glucose by consuming oxygen to generate H2O2 and enhance the local acidity, and the Pt layer exhibited peroxidase-like property to catalyze H2O2 producing toxic ·OH for tumor oxidative damage. Here we demonstrated that our probes simultaneously possessed a GSH-sensitive release, real-time imaging ability, and synergetic cancer starving-like therapy/enzyme oxidative therapy/PTT/PDT features, which provides a potential strategy for effective tumor theragnostic.}
}