@article{Lin2020, 
author = {Gan Lin and Yang Zhang and Long Zhang and Junqing Wang and Ye Tian and Wen Cai and Shangui Tang and Chengchao Chu and JiaJing Zhou and Peng Mi and Xiaoyuan Chen and Gang Liu},
title = {Metal-organic frameworks nanoswitch: Toward photo-controllable endo/lysosomal rupture and release for enhanced cancer RNA interference},
year = {2020},
journal = {Nano Research},
volume = {13},
number = {1},
pages = {238-245},
keywords = {metal-organic frameworks, cancer therapy, endo/lysosomal rupture and release, photo-controllable nanoswitch, RNA interference},
url = {https://www.sciopen.com/article/10.1007/s12274-019-2606-2},
doi = {10.1007/s12274-019-2606-2},
abstract = {Endo/lysosomal escape and gene release are two critical bottlenecks in gene delivery. Herein, a novel photo-controllable metal-organic frameworks (MOFs) nanoswitch is rationally designed for enhancing small interfering RNA (siRNA) delivery. One single laser triggers the "off-to-on" switching of MOFs nanocomplexes, inducing significant siRNA release accompanied by rapid MOFs dissociation into protonatable 2-methylimidazalo and osmotic rupturing Zn2+ ions, which cooperatively contribute to remarkable endo/lysosomal rupture (~ 90%). The simultaneous endo/lysosomal rupture and release enable a high spatio-temporal control on RNA interference for effective cancer therapy. Notably, the "off-to-on" switching also activates fluorescence recovery for real-time monitoring siRNA delivery. The nanoswitch could easily be extended to deliver other therapeutic agents (e.g., DNA, protein, anticancer drug) for overcoming endo/lysosomal entrapment.}
}