TY  - JOUR
AU  - Hu, Xiaona
AU  - Zhao, Yuyun
AU  - Hu, Zhijian
AU  - Saran, Aditya
AU  - Hou, Shuai
AU  - Wen, Tao
AU  - Liu, Wenqi
AU  - Ji, Yinglu
AU  - Jiang, Xingyu
AU  - Wu, Xiaochun
PY  - 2013
TI  - Gold nanorods core/AgPt alloy nanodots shell: A novel potent antibacterial nanostructure
JO  - Nano Research
SN  - 1998-0124
SP  - 822
EP  - 835
VL  - 6
IS  - 11
AB  - In the light of the current problems of silver nanoparticles (Ag NPs) in terms of antibacterial performance, we have designed a novel trimetallic core/shell nanostructure with AgPt alloy nanodots epitaxially grown on gold nanorods (Au@PtAg NRs) as a potential antibacterial agent. Both Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) were studied. The antibacterial activity exhibits an obvious composition-dependence. On increasing the Ag fraction in the alloy shell up to 80%, the antibacterial activity gradually increases, demonstrating a flexible way to tune this activity. At 80% Ag, the antibacterial activity is better than that of a pure Ag shell. The improved antibacterial ability mainly results from the high exposure of silver on the shell surface due to the dot morphology. We thus demonstrate that forming alloys is an effective way to improve antibacterial activity while retaining high chemical stability for Ag-based nanomaterials. Furthermore, due to the tunable localized surface plasmonic response in the near-infrared (NIR) spectral region, additional control over antibacterial activity using light—such as photothermal killing and photo-triggered silver ion release—is expected. As a demonstration, highly enhanced antibacterial activity is shown by utilizing the NIR photothermal effect of the nanostructures. Our results indicate that such tailored nanostructures will find a role in the future fight against bacteria, including the challenge of the increasing severity of multidrug resistance.
UR  - https://doi.org/10.1007/s12274-013-0360-4
DO  - 10.1007/s12274-013-0360-4