@article{Jiang2015, 
author = {Yuanyuan Jiang and Zijian Deng and Dan Yang and Xin Deng and Qi Li and Yinlin Sha and Changhui Li and Dongsheng Xu},
title = {Gold nanoflowers for 3D volumetric molecular imaging of tumors by photoacoustic tomography},
year = {2015},
journal = {Nano Research},
volume = {8},
number = {7},
pages = {2152-2161},
keywords = {nanoparticles, gold nanoflowers, contrast agents, photoacoustic tomography, tumor imaging, molecular imaging},
url = {https://www.sciopen.com/article/10.1007/s12274-014-0688-4},
doi = {10.1007/s12274-014-0688-4},
abstract = {By binding molecular probes that target tumor cells, gold nanoparticles (AuNPs) with superior characteristics have shown great potential in tumor molecular imaging studies. The non-invasive, high-resolution, and three-dimensional imaging of the targeted AuNPs within the tumor is desirable for both diagnosis and therapy. In this study, gold nanoflowers (AuNFs) are presented as a novel contrast agent for photoacoustic tomography (PAT). By binding to folic acid, the molecular probe, the tail-vein injected AuNFs concentrated within the tumor site in mice; this was clearly visualized by three-dimensional (3D) PAT imaging. In addition, toxicity assay proved that AuNFs were harmless to living cells and animals. Our results demonstrate that AuNFs have great potential in tumor molecular imaging.}
}