@article{Luo2015, 
author = {Guofeng Luo and Weihai Chen and Huizhen Jia and Yunxia Sun and Han Cheng and Renxi Zhuo and Xianzheng Zhang},
title = {An indicator-guided photo-controlled drug delivery system based on mesoporous silica/gold nanocomposites},
year = {2015},
journal = {Nano Research},
volume = {8},
number = {6},
pages = {1893-1905},
keywords = {MSN/Au nanocomposite, photo-controlled, MMP-2 sensitive, drug delivery, tumor therapy},
url = {https://www.sciopen.com/article/10.1007/s12274-014-0698-2},
doi = {10.1007/s12274-014-0698-2},
abstract = {A mesoporous silica/gold (MSN/Au) nanocomposite was designed for photo-controlled drug delivery targeted specifically at tumor cells. The MSN/Au nanocomposite was composed of MSN-based drug carriers and gold nanoparticle (AuNP)-based indicators. While the MSN-based drug carrier was a mesoporous silica nanoparticle immobilized with photo-switchable azobenzene (Azo) moieties, the AuNP-based indicator was a fluorescence-quenched AuNP modified with a matrix metalloproteinase (MMP) substrate and poly(ethylene glycol). The two kinds of nanoparticles were connected by an α, β cyclodextrin (α, β CD) dimer "bridge." In vitro studies demonstrated that the nanocomposite specifically interacted with tumor sites overexpressing MMP-2, which enabled guidance of the subsequent UV light irradiation for releasing entrapped drugs. Through integration of the AuNP-based indicator and the MSN-based drug carrier, the MSN/Au nanocomposite could precisely localize the released drug to tumor sites, thereby significantly improving therapeutic efficacy.}
}