@article{Chen2015, 
author = {Yinyin Chen and Shi Liu and Zhiyao Hou and Pingan Ma and Dongmei Yang and Chunxia Li and Jun Lin},
title = {Multifunctional electrospinning composite fibers for orthotopic cancer treatment in vivo},
year = {2015},
journal = {Nano Research},
volume = {8},
number = {6},
pages = {1917-1931},
keywords = {treatment, controlled release, electrospinning orthotopic, multiple structure},
url = {https://www.sciopen.com/article/10.1007/s12274-014-0701-y},
doi = {10.1007/s12274-014-0701-y},
abstract = {A multifunctional, dual-drug carrier platform was successfully constructed. Core-shell structured NaGdF4: Yb/Er@NaGdF4: Yb@mSiO2-polyethylene glycol (abbreviated as UCNPS) nanoparticles loaded with the antitumor drug, doxorubicin (DOX) were incorporated into poly(ε-caprolactone) (PCL) and gelatin loaded with antiphlogistic drug, indomethacin (MC) to form nanofibrous fabrics (labeled as MC/UCNPS/DOX) via electrospinning process. The resultant multifunctional spinning pieces can be surgically implanted directly at the tumor site of mice as an orthotopic chemotherapy by controlled-release DOX from mesoporous silicon dioxide (SiO2) and upconversion fluorescence/magnetic resonance dual-model imaging through NaGdF4: Yb/Er@NaGdF4: Yb embedded in MC/UCNPS/DOX in vivo.}
}