@article{Liu2021, 
author = {Chaoyong Liu and Jing Wen and Dai Li and Hongzhao Qi and Lina Nih and Jialin Zhu and Duo Xu and Yu Ren and Shanshan Zhang and Donglin Han and Huanhuan Jia and Junhu Zhou and Meng Qin and Jialing Wu and Xubo Yuan and Ji Liu and Jin Zhao and Chunsheng Kang and Yunfeng Lu},
title = {Systemic delivery of microRNA for treatment of brain ischemia},
year = {2021},
journal = {Nano Research},
volume = {14},
number = {9},
pages = {3319-3328},
keywords = {polymer nanocapsules, small RNA delivery, microRNA-21, brain ischemia},
url = {https://www.sciopen.com/article/10.1007/s12274-021-3413-8},
doi = {10.1007/s12274-021-3413-8},
abstract = {Brain ischemia is the second leading cause of death and the third leading cause of disability in the world. Systemic delivery of microRNA, a class of molecules that regulate the expression of cellular proteins associated with angiogenesis, cell growth, proliferation and differentiation, holds great promise for the treatment of brain ischemia. However, their therapeutic efficacy has been hampered by poor delivery efficiency of microRNA. We report herein a platform technology based on microRNA nanocapsules, which enables their effective delivery to the disease sites in the brain. Exemplified by microRNA-21, intravenous injection of the nanocapsules into a rat model of cerebral ischemia could effectively ameliorate the infarct volume, neurological deficit and histopathological severity.}
}