TY  - JOUR
AU  - Feng, Lingyan
AU  - Li, Wen
AU  - Ren, Jinsong
AU  - Qu, Xiaogang
PY  - 2015
TI  - Electrochemically and DNA-triggered cell release from ferrocene/β-cyclodextrin and aptamer modified dualfunctionalized graphene substrate
JO  - Nano Research
SN  - 1998-0124
SP  - 887
EP  - 899
VL  - 8
IS  - 3
AB  - Here we report a dual-functionalized electrochemical substrate to trigger cancer cells release based on the supramolecular interaction between β-cyclodextrin (β-CD) and Fc on clinical trial Ⅱ aptamer AS1411 functionalized graphene platform. On one hand, the host-guest interaction can be reversible electrochemically controlled to realize cancer cells capture/release, and 1-adamantylamine binding can further amplify this surface change by competing interaction with β-CD. On the other hand, the AS1411 aptamer and its complementary DNA (cDNA) also can be used as a switchable anchor for cell adhesion. Our work gives an example for label-free, multi-functionalized triggered cell release based on aptamer and β-CD/graphene-modified surface and this multi-ways for cell catch-and-release on graphene modified surface also provides their potential biomedical application.
UR  - https://doi.org/10.1007/s12274-014-0570-4
DO  - 10.1007/s12274-014-0570-4