@article{Luo2021, 
author = {Feng-Qin Luo and Guojun Chen and Wei Xu and Daojia Zhou and Jia-Xian Li and Yong-Cong Huang and Run Lin and Zhen Gu and Jin-Zhi Du},
title = {Microneedle-array patch with pH-sensitive formulation for glucose-responsive insulin delivery},
year = {2021},
journal = {Nano Research},
volume = {14},
number = {8},
pages = {2689-2696},
keywords = {drug delivery, pH-sensitive, diabetes, glucose-responsive, microneedle},
url = {https://www.sciopen.com/article/10.1007/s12274-020-3273-z},
doi = {10.1007/s12274-020-3273-z},
abstract = {Glucose-responsive insulin delivery systems show great promise to improve therapeutic outcomes and quality of life for people with diabetes. Herein, a new microneedle-array patch containing pH-sensitive insulin-loaded nanoparticles (NPs) (SNP(I)) together with glucose oxidase (GOx)- and catalase (CAT)-loaded pH-insensitive NPs (iSNP(G+C)) is constructed for transcutaneous glucose-responsive insulin delivery. SNP(I) are prepared via double emulsion from a pH-sensitive amphiphilic block copolymer, and undergo rapid dissociation to promote insulin release at a mild acidic environment induced by GOx in iSNP(G+C) under hyperglycemic conditions. CAT in iSNP(G+C) can further consume excess H2O2 generated during GOx oxidation, and thus reduce the risk of inflammation toward the normal skin. The in vivo study on type 1 diabetic mice demonstrates that the platform can effectively regulate blood glucose levels within normal ranges for a prolonged period.}
}