@article{Li2021, 
author = {Yafei Li and Wen Lv and Lang Wang and Yaming Zhang and Lipeng Yang and Tianyi Wang and Linyong Zhu and Yufeng Wang and Weiping Wang},
title = {Photo-triggered nucleus targeting for cancer drug delivery},
year = {2021},
journal = {Nano Research},
volume = {14},
number = {8},
pages = {2630-2636},
keywords = {phototargeting, dePEGylation, nucleus targeting, coumarin, photoresponsive prodrugs},
url = {https://www.sciopen.com/article/10.1007/s12274-020-3264-0},
doi = {10.1007/s12274-020-3264-0},
abstract = {Here, we report a strategy to deliver drug nanoparticles into cells with nucleus-targeting ability under a spatiotemporal control. The nanoparticles were constructed through self-assembly of photoresponsive prodrugs and free drugs. By incorporating a nucleus localization sequence in the system, drug nanoparticles could be delivered into nuclei upon visible light irradiation. The drug nanoparticles showed high drug loading capacity and specific nucleus-targeting ability, which efficiently killed cancer cells. This self-assembly strategy could be applied to other hydrophobic drugs and targeting ligands for photo-controlled organelle-targeted drug delivery.}
}