@article{Zou2016, 
author = {Yuxiu Zou and Long Chen and Zhiling Song and Ding Ding and Yiqin Chen and Yiting Xu and Shanshan Wang and Xiaofang Lai and Yin Zhang and Yang Sun and Zhuo Chen and Weihong Tan},
title = {Stable and unique graphitic Raman internal standard nanocapsules for surface-enhanced Raman spectroscopy quantitative analysis},
year = {2016},
journal = {Nano Research},
volume = {9},
number = {5},
pages = {1418-1425},
keywords = {graphitic nanomaterials, analytical methods, internal standards, quantitative analysis, surface-enhanced Raman spectroscopy (SERS)},
url = {https://www.sciopen.com/article/10.1007/s12274-016-1037-6},
doi = {10.1007/s12274-016-1037-6},
abstract = {Graphitic nanomaterials have unique, strong, and stable Raman vibrations that have been widely applied in chemistry and biomedicine. However, utilizing them as internal standards (ISs) to improve the accuracy of surface-enhanced Raman spectroscopy (SERS) analysis has not been attempted. Herein, we report the design of a unique IS nanostructure consisting of a large number of gold nanoparticles (AuNPs) decorated on multilayered graphitic magnetic nanocapsules (AGNs) to quantify the analyte and eliminate the problems associated with traditional ISs. The AGNs demonstrated a unique Raman band from the graphitic component, which was localized in the Raman silent region of the biomolecules, making them an ideal IS for quantitative Raman analysis without any background interference. The IS signal from the AGNs also indicated superior stability, even under harsh conditions. With the enhancement of the decorated AuNPs, the AGN nanostructures greatly improved the quantitative accuracy of SERS, in particular the exclusion of quantitative errors resulting from collection loss and non-uniform distribution of the analytes. The AGNs were further utilized for cell staining and Raman imaging, and they showed great promise for applications in biomedicine.}
}