@article{Ou2016, 
author = {Gang Ou and Zhiwei Li and Dongke Li and Liang Cheng and Zhuang Liu and Hui Wu},
title = {Photothermal therapy by using titanium oxide nanoparticles},
year = {2016},
journal = {Nano Research},
volume = {9},
number = {5},
pages = {1236-1243},
keywords = {photothermal therapy, titanium oxides, biocompatibility, photothermal conversion},
url = {https://www.sciopen.com/article/10.1007/s12274-016-1019-8},
doi = {10.1007/s12274-016-1019-8},
abstract = {The photothermal therapy (PTT) technique is regarded as a promising method for cancer treatment. However, one of the obstacles preventing its clinical application is the non-degradability and biotoxicity of the existing heavy-metal and carbon-based therapeutic agents. Therefore, a PTT material with a high photothermal efficiency, low toxicity, and good biocompatibility is urgently wanted. Herein, we report a titanium oxide-based therapeutic agent with a high efficacy and low toxicity for the PTT process. We demonstrated that Magnéli-phase Ti8O15 nanoparticles fabricated by the arc-melting method exhibit > 98% absorption of near infrared light and a superior photothermal therapy effect in the in vivo mouse model. The Ti8O15 nanoparticle PTT material also shows a good biocompatibility and biosafety. Our study reveals Magnéli-phase titanium oxide as a new family of PTT agents and introduces new applications of titanium oxides for photothermal conversion.}
}