@article{Wang2018, 
author = {Wei Wang and Yang Zhao and Bei-Bei Yan and Liang Dong and Yang Lu and Shu-Hong Yu},
title = {Calcium carbonate-doxorubicin@silica-indocyanine green nanospheres with photo-triggered drug delivery enhance cell killing in drug-resistant breast cancer cells},
year = {2018},
journal = {Nano Research},
volume = {11},
number = {6},
pages = {3385-3395},
keywords = {calcium carbonate-based structures, photothermal therapy, photodynamic therapy, combined therapeutic effects},
url = {https://www.sciopen.com/article/10.1007/s12274-017-1950-3},
doi = {10.1007/s12274-017-1950-3},
abstract = {Calcium carbonate-doxorubicin@silica-indocyanine green nanospheres with high uniformity and monodispersity were designed and synthesized, in order to provide a photo-triggered strategy for drug-resistant cancer therapy. Under near-infrared laser irradiation, the nanospheres transformed laser power into local heat and reactive oxygen species via the connected indocyanine green molecule, thus exhibiting photothermal and photodynamic effects. Moreover, the photo-triggered drug release based on calcium-assisted silica degradation was observed, endowing the nanospheres with chemotherapeutic properties. Finally, combined therapeutic effects against drug-resistant human breast cancer cells were successfully obtained. These photo-triggered materials based on calcium carbonate could provide a promising platform for enhanced multimodal cancer therapies.}
}