@article{Lou2012, 
author = {Lei Lou and Ke Yu and Zhengli Zhang and Rong Huang and Jianzhong Zhu and Yiting Wang and Ziqiang Zhu},
title = {Dual-Mode Protein Detection Based on Fe3O4–Au Hybrid Nanoparticles},
year = {2012},
journal = {Nano Research},
volume = {5},
number = {4},
pages = {272-282},
keywords = {Fe3O4, Au, electrochemical immunosensor, surface-enhanced Raman scattering},
url = {https://www.sciopen.com/article/10.1007/s12274-012-0207-4},
doi = {10.1007/s12274-012-0207-4},
abstract = {A facile method of synthesizing Fe3O4–Au hybrid nanoparticles is reported utilizing the multifunctional nature of polyethyleneimine (PEI). An abundance of 5 nm gold nanoparticles were attached to 50 nm Fe3O4 nanoparticles via the covalent binding between the −NH2 groups of the PEI and Au nanoparticles, as well as the electrostatic interaction between the negatively charged citrate-coated Au nanoparticles and the positively charged PEI-coated Fe3O4 nanoparticles. The as-prepared Fe3O4–Au hybrid nanoparticles, which combine the merits of magnetic materials and gold, were successfully employed for the first time in the dual-mode detection of carcinoembryonic antigen (CEA) via electrochemical and surface-enhanced Raman scattering (SERS) methods. Both methods make clever use of Fe3O4–Au nanoparticles and can accurately verify the presence of antigens. In particular, the electrochemical immunosensor detection displays a wide linear range (0.01–10 ng/mL) of response with a low detection limit (10 pg/mL), while the SERS method responds to even lower antigen concentrations with a wider detection range. The Fe3O4–Au hybrid nanoparticles therefore exhibit great potential for biomedical applications.}
}