@article{Kuo2014, 
author = {Tsungrong Kuo and Weiyun Lai and Chenghung Li and Yanjhan Wun and Huancheng Chang and Jinnshiun Chen and Panchyr Yang and Chiachun Chen},
title = {AS1411 aptamer-conjugated Gd2O3: Eu nanoparticles for target-specific computed tomography/magnetic resonance/fluorescence molecular imaging},
year = {2014},
journal = {Nano Research},
volume = {7},
number = {5},
pages = {658-669},
keywords = {aptamer, contrast agent, Gd2O3 nanoparticles, molecular imaging, nanoparticles synthesis},
url = {https://www.sciopen.com/article/10.1007/s12274-014-0420-4},
doi = {10.1007/s12274-014-0420-4},
abstract = {Europium-doped gadolinium oxide (Gd2O3: Eu) nanoparticles have been synthesized, and then their surfaces have been conjugated with nucleolintargeted AS1411 aptamer to form functionalized target-specific Gd2O3: Eu nanoparticles (A-GdO: Eu nanoparticles). The A-GdO: Eu nanoparticles present strong fluorescence in the visible range, high magnetic susceptibility, X-ray attenuation and good biocompatibility. The A-GdO: Eu nanoparticles have been applied to test molecular expression of nucleolin highly expressed CL1-5 lung cancer cells under a confocal microscope. Fluorescence imaging clearly reveals that the nanoparticles can be applied as fluorescent tags for cancer-targeting molecular imaging. Furthermore, taking together their excellent T1 contrast and strong computed tomography (CT) signal, the A-GdO: Eu nanoparticles demonstrate a great capability for use as a dual modality contrast agent for CT and magnetic resonance (MR) molecular imaging. Animal experiments also show that the A-GdO: Eu nanoparticles are able to contrast the tissues of BALB/c mice using CT modality. Moreover, the obvious red fluorescence of A-GdO: Eu nanoparticles can be visualized in a tumor by the naked eye. Overall, our results demonstrate that the A-GdO: Eu nanoparticles can not only serve as new medical contrast agents but also as intraoperative fluorescence imaging probes for guided surgery in the near future.}
}