@article{Jiang2019, 
author = {Dawei Jiang and Hyung-Jun Im and Madeline E. Boleyn and Christopher G. England and Dalong Ni and Lei Kang and Jonathan W. Engle and Peng Huang and Xiaoli Lan and Weibo Cai},
title = {Efficient renal clearance of DNA tetrahedron nanoparticles enables quantitative evaluation of kidney function},
year = {2019},
journal = {Nano Research},
volume = {12},
number = {3},
pages = {637-642},
keywords = {DNA nanotechnology, positron emission tomography (PET) imaging, DNA tetrahedron nanoparticle, renal clearance, kidney dysfunction},
url = {https://www.sciopen.com/article/10.1007/s12274-019-2271-5},
doi = {10.1007/s12274-019-2271-5},
abstract = {DNA tetrahedron nanostructure (DTN) is one of the simplest DNA nanostructures and has been successfully applied for biosensing, imaging, and treatment of cancer. To facilitate its biomedical applications and potential clinical translation, fundamental understanding of DTN's transportation among major organs in living organisms becomes increasingly important. Here, we describe the efficient renal clearance of DTN in healthy mice by using positron emission tomography (PET) imaging. The kidney elimination of DTN was later applied for renal function evaluation in murine models of unilateral ureteral obstruction (UUO). We further established a mathematical program of DTN to validate its changes of transportation pattern in healthy and UUO mice. We believe the establishment of pharmacokinetic profiles and mathematical model of DTN may provide insight for future optimization of DNA nanostructures for biomedical applications.}
}