@article{Zhu2019, 
author = {Wenjun Zhu and Yu Yang and Qiutong Jin and Yu Chao and Longlong Tian and Jingjing Liu and Ziliang Dong and Zhuang Liu},
title = {Two-dimensional metal-organic-framework as a unique theranostic nano-platform for nuclear imaging and chemo-photodynamic cancer therapy},
year = {2019},
journal = {Nano Research},
volume = {12},
number = {6},
pages = {1307-1312},
keywords = {drug delivery, photodynamic therapy, nanoscale metal-organic-framework, two-dimensional nanosheets, combination},
url = {https://www.sciopen.com/article/10.1007/s12274-018-2242-2},
doi = {10.1007/s12274-018-2242-2},
abstract = {Nanoscale metal organic frameworks (NMOFs) with porous structure and inherent biodegradability are attractive nanomedicine platforms. In addition to conventional particulate NMOFs, two-dimensional (2D) NMOFs are emerging as a unique type of NMOFs which however have been relatively less explored for nanomedicine applications. Herein, 2D NMOFs composed of Zn2+ and tetrakis(4-carboxyphenyl) porphyrin (TCPP) are fabricated and functionalized with polyethylene glycol (PEG). Compared to their particulate counterpart, such 2D NMOFs show greatly increased drug loading capacity and enhanced light-triggered singlet oxygen production, promising for chemotherapy and photodynamic therapy (PDT), respectively. Utilizing the porphyrin structure of TCPP, our 2D NMOFs could be labeled with a diagnostic radioisotope, 99mTc, for single photon emission computer tomography (SPECT) imaging, which reveals efficient tumor homing of those 2D NMOFs upon intravenous injection. While offering a remarkable synergistic in vivo antitumor effect for the combined chemo-PDT, such 2D NMOFs show efficient biodegradation and rapid renal clearance. Our work presents the great promise of 2D NMOFs for nanomedicine applications.}
}