@article{Chong2021, 
author = {Gaowei Chong and Jie Zang and Yi Han and Runping Su and Nopphon Weeranoppanant and Haiqing Dong and Yongyong Li},
title = {Bioengineering of nano metal-organic frameworks for cancer immunotherapy},
year = {2021},
journal = {Nano Research},
volume = {14},
number = {5},
pages = {1244-1259},
keywords = {cancer immunotherapy, nano metal-organic frameworks (nMOFs), bioengineering, vaccine delivery, tumor-microenvironment modulation},
url = {https://www.sciopen.com/article/10.1007/s12274-020-3179-9},
doi = {10.1007/s12274-020-3179-9},
abstract = {Immunotherapy techniques, such as immune checkpoint inhibitors, chimeric antigen receptor (CAR) T cell therapies and cancer vaccines, have been burgeoning with great success, particularly for specific cancer types. However, side effects with fatal risks, dysfunction in tumor microenvironment and low immune response rates remain the bottlenecks in immunotherapy. Nano metal-organic frameworks (nMOFs), with an accurate structure and a narrow size distribution, are emerging as a solution to these problems. In addition to their function of temporospatial delivery, a large library of their compositions, together with flexibility in chemical interaction and inherent immune efficacy, offers opportunities for various designs of nMOFs for immunotherapy. In this review, we overview state-of-the-art research on nMOFs-based immunotherapies as well as their combination with other therapies. We demonstrate that nMOFs are predominantly customized for vaccine delivery or tumor-microenvironment modulation. Finally, a prospect of nMOFs in cancer immunotherapy will be discussed.}
}