@article{Yang2018, 
author = {Xinglong Yang and Lingmin Zhang and Xingyu Jiang},
title = {Aminosaccharide–gold nanoparticle assemblies as narrow-spectrum antibiotics against methicillin-resistant Staphylococcus aureus},
year = {2018},
journal = {Nano Research},
volume = {11},
number = {12},
pages = {6237-6243},
keywords = {gold nanoparticles, multivalent aminosaccharides, antibacterial activity, methicillin-resistant Staphylococcus aureus (MRSA), antibiotics},
url = {https://www.sciopen.com/article/10.1007/s12274-018-2143-4},
doi = {10.1007/s12274-018-2143-4},
abstract = {Bacterial infection has continued to be a leading cause of death or disability worldwide because of antibiotic resistance. Antibiotic agents specific to certain taxa of bacteria, i.e., narrow-spectrum antibiotics, have become useful because they can kill bacteria without resulting in broad-spectrum drug resistance. In this study, we describe a series of antibiotics based on combining gold nanoparticles (AuNPs) with aminosaccharides, even though these AuNPs or aminosaccharides by themselves are ineffective against any bacteria. The AuNP-based multivalent aminosaccharides can effectively and selectively inhibit the growth of Gram-positive bacteria (including drug-resistant superbacteria). In particular, aminosaccharide-modified AuNPs are effective against methicillin-resistant Staphylococcus aureus (MRSA), a particularly hard-to-treat strain. This report carves out a way to explore antibiotics by combining AuNPs and an aminosaccharide as multivalent nanostructures, neither of which by itself is effective as an antibiotic.}
}