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Mini Review | Open Access

Potential of adipose derived stem cell preparations in neurological repair and regeneration

Laura Combes1( )Xenia Sawkulycz1( )Wen-Hui Fang2Baoqiang Guo1Mark Slevin1( )
Department of Life Sciences, Manchester Metropolitan University, Manchester, UK
Department of Biological and Geographical Sciences University of Huddersfield, Huddersfield, UK
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Graphical Abstract

Abstract

Stem cell therapy is a promising treatment for neurogenerative disease as well as inflammatory and immune mediated diseases. Decades of preclinical research has demonstrated stem cell ability to differentiate into multiple cell lineages and be utilised in regeneration and repair with their immunomodulatory and immunosuppressive properties. This work has provided the fundamental scientific knowledge needed to launch various clinical trials studying stem cell therapy in autoimmune disorders, stroke, and other tissue injury. Despite the early success many of these promising therapies are yet to breakthrough into clinical use. In this review, we highlight the recent developments in the use of stem cells as therapeutic agents for neurological conditions as well as their failures and how the clinical translation can be improved.

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Biophysics Reports
Pages 81-90
Cite this article:
Combes L, Sawkulycz X, Fang W-H, et al. Potential of adipose derived stem cell preparations in neurological repair and regeneration. Biophysics Reports, 2021, 7(2): 81-90. https://doi.org/10.52601/bpr.2021.200025

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Received: 09 July 2020
Accepted: 06 February 2021
Published: 17 May 2021
© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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