AI Chat Paper
Note: Please note that the following content is generated by AMiner AI. SciOpen does not take any responsibility related to this content.
{{lang === 'zh_CN' ? '文章概述' : 'Summary'}}
{{lang === 'en_US' ? '中' : 'Eng'}}
Chat more with AI
View PDF
Submit Manuscript AI Chat Paper
Show Outline
Show full outline
Hide outline
Show full outline
Hide outline
Mini Review | Open Access

Potential of adipose derived stem cell preparations in neurological repair and regeneration

Laura Combes1( )Xenia Sawkulycz1( )Wen-Hui Fang2Baoqiang Guo1Mark Slevin1( )
Department of Life Sciences, Manchester Metropolitan University, Manchester, UK
Department of Biological and Geographical Sciences University of Huddersfield, Huddersfield, UK
Show Author Information

Graphical Abstract


Stem cell therapy is a promising treatment for neurogenerative disease as well as inflammatory and immune mediated diseases. Decades of preclinical research has demonstrated stem cell ability to differentiate into multiple cell lineages and be utilised in regeneration and repair with their immunomodulatory and immunosuppressive properties. This work has provided the fundamental scientific knowledge needed to launch various clinical trials studying stem cell therapy in autoimmune disorders, stroke, and other tissue injury. Despite the early success many of these promising therapies are yet to breakthrough into clinical use. In this review, we highlight the recent developments in the use of stem cells as therapeutic agents for neurological conditions as well as their failures and how the clinical translation can be improved.



Aboody KS, Najbauer J, Metz MZ, D'Apuzzo M, Gutova M, Annala AJ, Synold TW, Couture LA, Blanchard S, Moats RA, Garcia E, Aramburo S, Valenzuela VV, Frank RT, Barish ME, Brown CE, Kim SU, Badie B, Portnow J (2013) Neural stem cell-mediated enzyme/prodrug therapy for glioma: preclinical studies. Sci Transl Med 5(184): 184ra59.


Acosta SA, Tajiri N, Hoover J, Kaneko Y (2015) Intravenous bone marrow stem cell grafts preferentially migrate to spleen and abrogate chronic inflammation in stroke. Stroke 46(9): 2616−2627


Ahmed AS, Sheng MH, Wasnik S, Baylink DJ, Lau KW (2017) Effect of aging on stem cells. World J Exp Med 7(1): 1−10


Bang OY (2016) Clinical trials of adult stem cell therapy in patients with ischemic stroke. J Clin Neurol 12(1): 14−20


Boehme A, Esenwa C, Elkind M (2017) Stroke risk factors, genetics, and prevention. Circ Res 120(3): 472−495


Cho S-W, Kim S-S, Won Rhie J, Mi Cho H, Yong Choi C, Kim B-S (2005) Engineering of volume-stable adipose tissues. Biomaterials 26(17): 3577−3585


Christiaens V, Lijnen HR (2010) Angiogenesis and development of adipose tissue. Mol Cell Endocrinol 318(1): 2−9


Coccè V, Farronato D, Brini A, Masia C, Giannì A, Piovani G, Sisto F, Alessandri G, Angiero F, Pessina A (2017) Drug loaded gingival mesenchymal stromal cells (GinPa-MSCs) inhibit in vitro proliferation of oral squamous cell carcinoma. Sci Rep 7(1): 9376.


Coccè V, Franzè S, Brini AT, Giannì AB, Pascucci L, Ciusani E, Alessandri G, Farronato G, Cavicchini L, Sordi V, Paroni R, Cas MD, Cilurzo F, Pessina A (2019) In vitro anticancer activity of extracellular vesicles (EVs) secreted by gingival mesenchymal stromal cells primed with paclitaxel. Pharmaceutics 11(2): 61.


Eyrich D, Göpferich A, Blunk T (2006) Fibrin in tissue engineering. Adv Exp Med Biol 585: 379−392


Fitzsimmons REB, Mazurek MS, Soos A, Simmons CA (2018) Mesenchymal stromal/stem cells in regenerative medicine and tissue engineering. Stem Cell Int 2018: 8031718.


Gesta S, Tseng Y-H, Kahn CR (2008) Developmental origin of fat: tracking obesity to its source. Cell 135(2): 366−366


Gomillion CT, Burg KJL (2006) Stem cells and adipose tissue engineering. Biomaterials 27(36): 6052−6063


Göpferich A (1996) Mechanisms of polymer degradation and erosion. Biomaterials 17(2): 103−114


Han Y, Li X, Zhang Y, Han Y, Chang F, Ding J (2019) Mesenchymal stem cells for regenerative medicine. Cells 8(8): 886.


Hossain J, Latif MA, Ystaas LAR, Ninzima S, Riecken K, Muller A, Azuaje F, Vareecal Joseph J, Talasila KM, Ghimire J, Fehse B, Bjerkvig R, Miletic H (2019) Long-term treatment with valganciclovir improves lentiviral suicide gene therapy of glioblastoma. Neuro Oncol 21(7): 890−900


Hsuan YCY, Lin CH, Chang CP, Lin MT (2016) Mesenchymal stem cell-based treatments for stroke, neural trauma, and heat stroke. Brain Behav 6(10): 1−11


Kawaguchi N, Toriyama K, Nicodemou-Lena E, Inou K, Torii S, Kitagawa Y (1998) De novo adipogenesis in mice at the site of injection of basement membrane and basic fibroblast growth factor. Proc Natl Acad Sci USA 95(3): 1062−1066


Kimura Y, Ozeki M, Inamoto T, Tabata Y (2002) Time course of de novo adipogenesis in matrigel by gelatin microspheres incorporating basic fibroblast growth factor. Tissue Eng 8(4): 603−613


Kievit E, Bershad E, Ng E, Sethna P, Dev I, Lawrence TS, Rehemtulla A (1999) Superiority of yeast over bacterial cytosine deaminase for enzyme/prodrug gene therapy in colon cancer xenografts. Cancer Res 59(7): 1417−1421


Korkegian A, Black ME, Baker D, Stoddard BL (2005) Computational thermostabilization of an enzyme. Science 308(5723): 857−860


Koton S, Telman G, Kimiagar I, Tanne D (2013) Gender differences in characteristics, management and outcome at discharge and three months after stroke in a national acute stroke registry. Int J Cardiol 168(4): 4081−4084


Koyuncu S, Irmak D, Saez I, Vilchez D (2015) Defining the general principles of stem cell aging: lessons from organismal models. Curr Stem Cell Rep 1: 162−169


Kurtzberg J, Prasad V, Grimley M, Horn B, Carpenter P, Jacobsohn D, Prockop S (2010) Allogeneic human mesenchymal stem cell therapy (Prochymal®) as a rescue agent for severe treatment resistant GVHD in pediatric patients. Biol Blood Marrow Transplant 16: S169.


Li S, Tokuyama T, Yamamoto J, Koide M, Yokota N, Namba H (2005) Bystander effect-mediated gene therapy of gliomas using genetically engineered neural stem cells. Cancer Gene Ther 12(7): 600−607


Li J, Mooney D (2016) Designing hydrogels for controlled drug delivery. Nat Rev Mater 1(12): 16071.


Miana VV, Prieto González EA (2018) Adipose tissue stem cells in regenerative medicine. Ecancer 12: 822.


Nava S, Sordi V, Pascucci L, Tremolada C, Ciusani E, Zeira O, Cadei M, Soldati G, Pessina A, Parati E, Slevin M, Alessandri G (2019) Long-lasting anti-inflammatory activity of human microfragmented adipose tissue. Stem Cell Int 2019: 5901479.


Momin EN, Mohyeldin A, Zaidi HA, Vela G, Quinones-Hinojosa A (2010) Mesenchymal stem cells: new approaches for the treatment of neurological diseases. Curr Stem Cell Res Ther 5(4): 326−344


Oberbauer E, Steffenhagen C, Wurzer C, Gabriel C, Redl H, Wolbank S (2015) Enzymatic and non-enzymatic isolation systems for adipose tissue-derived cells: current state of the art. Cell Regen 4: 7.


Panchal J, Malanga G, Sheinkop M (2018) Safety and efficacy of percutaneous injection of lipogems micro-fractured adipose tissue for osteoarthritic knees. Am J Orthop (Belle Mead NJ) 47(11).


Panés J, García-Olmo D, Van Assche G, Colombel JF, Reinisch W, Baumgart DC, Dignass A, Nachury M, Ferrante M, Kazemi-Shirazi L, Grimaud JC, de la Portilla F, Goldin E, Richard MP, Diez MC, Tagarro I, Leselbaum A, Danese S, ADMIRE CD Study Group Collaborators (2018) Long-term efficacy and safety of stem cell therapy (Cx601) for complex perianal fistulas in patients with Crohn's disease. Gastroenterology 154(5): 1334−1342


Patrick JCW, Chauvin PB, Hobley J, Reece GP (1999) Preadipocyte seeded PLGA scaffolds for adipose tissue engineering. Tissue Eng 5(2): 139−151


Popa-Wagner A, Buga A, Doeppner T, Hermann D (2014) Stem cell therapies in preclinical models of stroke associated with aging. Front Cell Neurosci 8: 347.


Popa-Wagner A, Petcu E, Capitanescu B, Hermann D, Radu E, Gresita A (2020) Ageing as a risk factor for cerebral ischemia: underlying mechanisms and therapy in animal models and in the clinic. Mech Ageing Dev 190: 111312.


Randelli P, Menon A, Ragone V, Creo P, Bergante S, Randelli F, De Girolamo L, Alfieri Montrasio U, Banfi G, Cabitza P, Tettamanti G, Anastasia L (2016) Lipogems product treatment increases the proliferation rate of human tendon stem cells without affecting their stemness and differentiation capability. Stem Cells Int 2016: 4373410.


Roato I, Mussano F, Reano S, Boriani F, Margara A, Ferracini R, Adriani E, SabryO, Fiorini M, Fattori P (2020) A novel method to optimize autologous adipose tissue recovery with extracellular matrix preservation. Processes 8(1): 88.


Srijaya T C, Ramasamy TS, Kasim NHA (2014) Advancing stem cell therapy from bench to bedside: lessons from drug therapies. J Transl Med 12: 243.


Tatarishvili J, Okia K, Monnia E, Kochb P, Memanishvilia T, Bugad AM, Vermaa V, Popa-Wagnerd A, Brustleb O, Lindvallaand O, Kokaiaa Z (2014) Human induced pluripotent stem cellsimprove recovery in stroke-injured aged rats. Restor Neurol Neurosci 32(4): 547−558


Tremolada C, Colombo V, Ventura C (2016) Adipose tissue and mesenchymal stem cells: state of the art and Lipogems® technology development. Curr Stem Cell Rep 2(3): 304−312


Trivisonno A, Alexander RW, Baldari S, Cohen SR, Di Rocco G, Gentile P, Magalon G, Magalon J, Miller RB, Womack H, Toietta G (2019) Intraoperative strategies for minimal manipulation of autologous adipose tissue for cell- and tissue-based therapies: concise review. Stem Cells Transl Med 8(12): 1265−1271


Tsuji W, Inamoto T, Yamashiro H, Ueno T, Kato H, Kimura Y, Tabata Y, Toi M (2009) Adipogenesis induced by human adipose tissue-derived stem cells. Tissue Eng 15(1): 83−93


von Heimburg D, Zachariah S, Kühling H, Heschel I, Schoof H, Hafemann B, Pallua N (2001) Human preadipocytes seeded on freeze-dried collagen scaffolds investigated in vitro and in vivo. Biomaterials 22(5): 429−438


Walton RL, Beahm K, Wu L (2004) De novo adipose formation in a vascularized engineered construct. Microsurgery 24(5): 378−384


Zeira O, Scaccia S, Pettinari L, Ghezzi E, Asiag N, Martinelli L, Zahirpour D, Dumas M, Konar M, Lupi D, Fiette L, Pascucci L, Leonardi L, Cliff A, Alessandri G, Pessina A, Spaziante D, Aralla M (2018) Intra-Articular administration of autologous micro-fragmented adipose tissue in dogs with spontaneous osteoarthritis: safety, feasibility, and clinical outcomes. Stem Cells Transl Med 7(11): 819−828

Biophysics Reports
Pages 81-90
Cite this article:
Combes L, Sawkulycz X, Fang W-H, et al. Potential of adipose derived stem cell preparations in neurological repair and regeneration. Biophysics Reports, 2021, 7(2): 81-90.












Received: 09 July 2020
Accepted: 06 February 2021
Published: 17 May 2021
© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit