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Case Report | Open Access

The Role of Ultrasonography in the Diagnosis of Systemic Sarcoidosis: a Case Report and Literature Review

Hui Lia,1Nan Zhengb,1Penglin ZouaChao JiaaLong LiuaGang LiaZiqi WangaRong WuaLianfang DuaQiusheng Shia( )
Department of Ultrasound, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Department of ultrasound, Henan Jiaozuo People's Hospital, Jiaozuo, China

1 Hui Li and Nan Zheng contributed equally to this work.

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Abstract

Sarcoidosis is a granulomatous disease of unknown etiology that can involve various organs and tissues. The clinical manifestations vary greatly, so it is difficult to make a clear diagnosis of sarcoidosis with just the clinical manifestation and imaging findings. The diagnosis and treatment of a patient with systemic sarcoidosis was reported: a 51-year-old woman presented with a dry cough. Computed tomography (CT), magnetic resonance imaging (MRI), and conventional ultrasonography (US) suggested miliary nodules and inflammatory changes in the lungs, there was mediastinal, retroperitoneal and hilar lymph node enlargement and uneven liver echo, respectively. Positron emission tomography/computed tomography (PET-CT) further suggested that the lesions were distributed throughout the body, including the lymph nodes and muscles of the extremities; thus, systemic lymphoma was considered. Finally, ultrasound-guided biopsy of different sites yielded the same histopathological findings: sarcoidosis. The sarcoidosis in this case is characterized by a large number of involved sites with a wide range, and a variety of imaging data were complete but failed to suggest a diagnosis. Finally, a clear histopathological result was obtained under the guidance of ultrasound. This article reviewed the relevant literature and concluded that ultrasound-guided puncture to obtain histopathological results is a simple and effective method for the diagnosis of sarcoidosis.

References

[1]

Drent M, Crouser ED, Grunewald J. Challenges of Sarcoidosis and its management. N Engl J Med 2021;385:1018-1032.

[2]

Jain R, Yadav D, Puranik N, Guleria R, Jin JO. Sarcoidosis: causes, diagnosis, clinical features, and treatments. J Clin Med 2020;9:1081.

[3]

Iannuzzi MC, Rybicki BA, Teirstein AS. Sarcoidosis. N Engl J Med 2007;357:2153-2165.

[4]

Brito-Zerón P, Kostov B, Superville D, Baughman RP, Ramos-Casals M; Autoimmune Big Data Study Group. Geoepidemiological big data approach to sarcoidosis: geographical and ethnic determinants. Clin Exp Rheumatol 2019;37:1052-1064.

[5]

Rybicki BA, Major M, Popovich J Jr, Maliarik MJ, Iannuzzi MC. Racial differences in sarcoidosis incidence: a 5-year study in a health maintenance organization. Am J Epidemiol 1997;145:234-241.

[6]

Hena KM. Sarcoidosis epidemiology: race matters. Front Immunol 2020;11:537382.

[7]

Kearney GD, Obi ON, Maddipati V, Mohan A, Malur A, Carter JC, et al. Sarcoidosis deaths in the United States: 1999-2016. Respir Med 2019;149:30-35.

[8]

Belperio JA, Shaikh F, Abtin FG, Fishbein MC, Weigt SS, Saggar R, et al. Diagnosis and treatment of pulmonary sarcoidosis: A Review. JAMA 2022;327:856-867.

[9]

Dempsey OJ, Paterson EW, Kerr KM, Denison AR. Sarcoidosis. BMJ 2009;339:b3206.

[10]

Statement on sarcoidosis. Joint statement of the American Thoracic Society (ATS), the European Respiratory Society (ERS) and the World Association of Sarcoidosis and Other Granulomatous Disorders (WASOG) adopted by the ATS Board of Directors and by the ERS Executive Committee, February 1999. Am J Respir Crit Care Med 1999;160:736-755.

[11]

Culver DA. Culver DA. Diagnosing sarcoidosis. Curr Opin Pulm Med 2015;21:499-509.

[12]

Trivieri MG, Spagnolo P, Birnie D, Liu P, Drake W, Kovacic JC, et al. Challenges in cardiac and pulmonary sarcoidosis: JACC state-of-the-art review. J Am Coll Cardiol 2020;76:1878-1901.

[13]

Nunes H, Bouvry D, Soler P, Valeyre D. Sarcoidosis. Orphanet J Rare Dis 2007;2:46.

[14]

Li CW, Tao RJ, Zou DF, Li MH, Xu X, Cao WJ. Pulmonary sarcoidosis with and without extrapulmonary involvement: a cross-sectional and observational study in China. BMJ Open 2018;8:e018865.

[15]

Vardhanabhuti V, Venkatanarasimha N, Bhatnagar G, Maviki M, Iyengar S, Adams WM, et al. Extra-pulmonary manifestations of sarcoidosis. Clin Radiol 2012;67:263-276.

[16]

Crouser ED, Maier LA, Wilson KC, Bonham CA, Morgenthau AS, Patterson KC, et al. Diagnosis and detection of sarcoidosis. An Official American Thoracic Society Clinical Practice Guideline. Am J Respir Crit Care Med 2020;201:e26-e51.

[17]

Spagnolo P, Rossi G, Trisolini R, Sverzellati N, Baughman RP, Wells AU. Pulmonary sarcoidosis. Lancet Respir Med 2018;6:389-402.

[18]

Criado E, Sánchez M, Ramírez J, Arguis P, de Caralt TM, Perea RJ, et al. Pulmonary sarcoidosis: typical and atypical manifestations at high-resolution CT with pathologic correlation. Radiographics 2010;30:1567-1586.

[19]

Koyama T, Ueda H, Togashi K, Umeoka S, Kataoka M, Nagai S. Radiologic manifestations of sarcoidosis in various organs. Radiographics 2004;24:87-104.

[20]

Vagal AS, Shipley R, Meyer CA. Radiological manifestations of sarcoidosis. Clin Dermatol 2007;25:312-325.

[21]

Nunes H, Brillet PY, Valeyre D, Brauner MW, Wells AU. Imaging in sarcoidosis. Semin Respir Crit Care Med 2007;28:102-120.

[22]

Tana C, Do Tana C, Donatiello I, Coppola MG, Ricci F, Maccarone MT, et al. CT Findings in pulmonary and abdominal sarcoidosis. Implications for diagnosis and classification. J Clin Med 2020;9:3028.

[23]

Mostard RL, Verschakelen JA, van Kroonenburgh MJ, Nelemans PJ, Wijnen PA, Vöö S, et al. Severity of pulmonary involvement and (18)F-FDG PET activity in sarcoidosis. Respir Med 2013;107:439-447.

[24]

Calandriello L, Walsh SLF. Imaging for sarcoidosis. Semin Respir Crit Care Med 2017;38:417-436.

[25]

Judson MA. Extrapulmonary sarcoidosis. Semin Respir Crit Care Med 2007;28:83-101.

[26]

Kumar M, Herrera JL. Sarcoidosis and the liver. Clin Liver Dis 2019;23:331-343.

[27]

Ungprasert P, Crowson CS, Simonetto DA, Matteson EL. Clinical characteristics and outcome of hepatic sarcoidosis: A Population-Based Study 1976-2013. Am J Gastroenterol 2017;112:1556-1563.

[28]

Ganeshan D, Menias CO, Lubner MG, Pickhardt PJ, Sandrasegaran K, Bhalla S. Sarcoidosis from head to toe: what the radiologist needs to know. Radiographics 2018;38:1180-1200.

[29]
Ebert EC, Kierson M, Hagspiel KD. Gastrointestinal and hepatic manifestations of sarcoidosis. Am J Gastroenterol 2008;103:3184-3192; quiz 3193.
[30]

Farman J, Ramirez G, Brunetti J, Tuvia J, Ng C, Rotterdam H. Abdominal manifestations of sarcoidosis. CT appearances. Clin Imaging 1995;19:30-33.

[31]

Karagiannidis A, Karavalaki M, Koulaouzidis A. Hepatic sarcoidosis. Ann Hepatol 2006;5:251-256.

[32]

Tana C, Dietrich CF, Schiavone C. Hepatosplenic sarcoidosis: contrast-enhanced ultrasound findings and implications for clinical practice. Biomed Res Int 2014;2014:926203.

[33]

Tana C, Silingardi M, Dietrich CF. New trends in ultrasound of hepatosplenic sarcoidosis. Z Gastroenterol 2015;53:283-284.

[34]

Soussan M, Augier A, Brillet PY, Weinmann P, Valeyre D. Functional imaging in extrapulmonary sarcoidosis: FDG-PET/CT and MR features. Clin Nucl Med 2014;39:e146-159.

[35]

Inaoka PT, Shono M, Kamada M, Espinoza JL. Host-microbe interactions in the pathogenesis and clinical course of sarcoidosis. J Biomed Sci 2019;26:45.

[36]

Kraaijvanger R, Janssen Bonás M, Vorselaars ADM, Veltkamp M. Biomarkers in the diagnosis and prognosis of sarcoidosis: current use and future prospects. Front Immunol 2020;11:1443.

[37]

Piekarski E, Benali K, Rouzet F. Nuclear imaging in sarcoidosis. Semin Nucl Med 2018;48:246-260.

[38]

Prasse A. The diagnosis, differential diagnosis, and treatment of sarcoidosis. Dtsch Arztebl Int 2016;113:565-574.

[39]

Huang Y, Shi J, Chen Y-Y, Li K. Ultrasound-guided percutaneous core needle biopsy for the diagnosis of pancreatic disease. Ultrasound in Medicine & Biology 2018;44:1145-1154.

[40]

Newell MS, Mahoney MC. Ultrasound-guided percutaneous breast biopsy. Techniques in Vascular and Interventional Radiology. 2014;17:23-31.

[41]

Wang X, Lv Y, Xu Z, Aniu M, Qiu Y, Wei B, et al. Accuracy and safety of ultrasound-guided percutaneous needle core biopsy of renal masses: A single center experience in China. Medicine (Baltimore) 2018;97:e0178.

Advanced Ultrasound in Diagnosis and Therapy
Pages 32-38
Cite this article:
Li H, Zheng N, Zou P, et al. The Role of Ultrasonography in the Diagnosis of Systemic Sarcoidosis: a Case Report and Literature Review. Advanced Ultrasound in Diagnosis and Therapy, 2024, 8(1): 32-38. https://doi.org/10.37015/AUDT.2024.230054

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Received: 21 November 2023
Revised: 12 December 2023
Accepted: 20 December 2023
Published: 30 March 2024
© AUDT 2024

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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