AI Chat Paper
Discover the SciOpen Platform and Achieve Your Research Goals with Ease.
Search articles, authors, keywords, DOl and etc.
{{expandStatus?'Exit ':''}}Advanced Search
Coreopsis tinctoria Nutt (C. tinctoria) or a common name ‘Snow chrysanthemum’ because of its growing condition at high altitude,is one of the popular medicinal-food plants, mainly grows in the northwest area of China. Because of its rich nutrients, particularly polyphenols (majorly flavonoids), and volatile oils among others, C. tinctoria has become a research hotspot in recent years. In addition, the flavonoids of C. tinctoria, especially the flavanomarein, marein, okanin and other bioactive phytochemicals, have effective biological activity. They possess good antioxidant and anti-inflammatory effects, also have significant effects on lowering blood pressure, hypoglycemia and reducing levels of triglycerides and cholesterol. However, at present, studies on the bioactivity of C. tinctoria are mainly focused on crude extracts or total flavonoids. The study of monomer components is largely limited to the isolation and purification process, which is difficult for a systematic study because of the chemical-physical nature of marein, flavanomarein and other compounds in C. tinctoria. Therefore, to have an updated isolation of C. tinctoria bioactive components, this paper reviewed the current research status of the separation and purification methods of flavonoids from C. tinctoria, by analyzing and comparing the technical characteristics of these methods, and providing prospects on the development and application of the separation and purification methods of C. tinctoria.
Begmatoy, N., Li, J., Bobakulov, K., Numonov, S., and Aisa, H.A. (2020). The chemical components of Coreopsis tinctoria Nutt. and their antioxidant, antidiabetic and antibacterial activities. Nat. Prod. Res. 34: 1772–1776.
Chen, L.X., Hu, D.J., Lam, S.C., He, L., Wu, D., Zhao, J., Long, Z.R., Yang, W.J., Fan, B., and Li, S.P. (2016). Comparison of antioxidant activities of different parts from snow chrysanthemum (Coreopsis tinctoria Nutt.) and identification of their natural antioxidants using high performance liquid chromatographycoupled with diode array detection and mass spectrometry and 2,2′-azinobis(3-ethylbenzthiazoline-sulfonic acid)diammoniumsalt-based assay. J. Chromatogr. A. 1428: 134–142.
Deng, Y., Lam, S.C., Zhao, J., and Li, S.P. (2017). Quantitative analysis of flavonoids and phenolic acid in Coreopsis tinctoria Nutt. by capillary zone electrophoresis. Electrophoresis 38(20): 2654–2661.
Du, D., Yao, L., Zhang, R., Shi, N., Shen, Y., Yang, X., Zhang, X., Jin, T., Liu, T., Hu, L., Xing, Z., Criddle, D.N., Xia, Q., Huang, W., and Sutton, R. (2018). Protective effects of flavonoids from Coreopsis tinctoria Nutt. on experimental acute pancreatitis via Nrf-2/ARE-mediated antioxidant pathways. J. Ethnopharmacol. 224: 261–272.
Guo, L., Zhang, W., Ho, C.-T., and Li, S. (2015). Chemistry and nutraceutical property of Coreopsis tinctoria. J. Funct. Foods. 13: 11–20.
Jiang, B.-P., Xu, L.-J., Jia, X.-G., and Xiao, P.-G. (2014). Research progress on the chemical constituents and pharmacological activities of Coreopsis tinctoria. Drugs Clin. 29: 567–573.
Lam, S.-C., Liu, X., Chen, X.-Q., Hu, D.-J., Zhan, J., Long, Z.-R., Fan, B., and Li, S.-P. (2016). Chemical characteristics of different parts of Coreopsis tinctoria in China using microwave-assisted extraction and high-performance liquid chromatography followed by chemometric analysis. J. Sep. Sci. 39: 2919–2927.
Li, N., Meng, D., Pan, Y., Cui, Q., Li, G., Ni, H., Sun, Y., Ding, D., Jia, X., Pan, Y., and Hou, Y. (2015). Anti-neuroinflammatory and NQO1 inducing activity of natural phytochemicals from Coreopsis tinctoria. J. Funct. Foods. 17: 837–846.
Li, S-F., Chen, X.-M., Ding, S., Qian, L., Zhang, D-X., and Zhang, Z.-J. (2021). Application progress of high speed countercurrent chromatography in the study of natural products. Storage and Process. 21(9): 122–128.
Liu, B.-A., Liu, J.-G., Liu, W., Pan, X.-B., Qi, Y., and Liu, Y.-M. (2014). Antioxidant activity of different solvent extracts from Coreopsis tinctoria. China Brewing 33(03): 71–75.
Liu, X.-F., Liu, L., Wang, Y.-G., Wang, X.-L., Leng, F.-F., Wang, Y.-L., Wang, S.-W., and Li, Y.-C. (2015). Optimization of ultrasonic-assisted extraction of total flavones from Coreopsis tinctoria Nutt. Romanian Biotech. Lett. 20: 10143–10150.
Ma, Z., Zheng, S., Han, H., Meng, J., Yang, X., Zeng, S., Zhou, H., and Jiang, H. (2016). The bioactive components of Coreopsis tinctoria (Asteraceae) capitula: Antioxidant activity in vitro and profile in rat plasma. J. Funct. Foods. 20: 575–586.
Ma, P., Yu, F., Zhong, Y., Xu, L., and Xiao, P. (2023). Protective effects of flavonoids in Coreopsis tinctoria Nutt. in a mouse model of type 2 diabetes. J Ethnopharmacol. 307: 116214.
Mawulies, N., Zhu, Q., Tumoer, T., Guli, J., Nuermaihemai, B., and Simayil, A. (2013). Study on purification tehnology for total flavonoids in Kunlun Chrysanthemum with poyamide resin. J. Xinjiang Med. Univ. 36(12): 1753–1756.
Qiu, L., Liu, Y., Zheng, N., Sog, M., Chen, N., Feng, R., Wang, Z., Zhou, Y., and Zhang, Q. (2022). Advances in research on the extraction and isolation techniques of natural products. Prog. Pharm. Sci. 46(3): 184–197.
Shao, D.-D., Chen, Q., Li, H.-Y., and Xiao, W.-P. (2018). Study on antioxidant activity of the extraction of Coreopsis tinctoria. Food Res. Develop. 39(15): 28–31.
Shen, J., Hu, M., Tan, W., Ding, J., Jiang, B., Xu, L., Hamulati, H., He, C., Sun, Y., and Xiao, P. (2021). Traditional use, phytochemistry, pharmacology, and toxicology of Coreopsis tinctoria Nutt.: A review. J. Ethnopharmacol. 269: 113690.
Song, Y-W., Jin, H-N., Xu, J., and Xie, H. (2016). Isolation and identification of the flavonoids compounds from Coreopsis tinctoria Nutt. and evaluation of their antioxidant activities. Food Ferment. Ind. 42(4): 220–223.
Sun, Y.-J., Sun, Y.-S., Chen, H., Hao, Z.-Y., Wang, J.-M., Guan, Y.-B., Zhang, Y.-L., Feng, W.-S., and Zheng, X.-K. (2014). Isolation of two new prenylated flavonoids from Sinopodophyllum emodi fruit by silica gel column and high-speed counter-current chromatography. J. Chromatogr. B 96: 190–198.
Wang, D., Yu, J., Zheng, Z., Song, X., Wang, D., and Wang, X. (2017). Separation and purification of 3,5-dicaffeoylquinic acid and okanin from Coreopsis tinctoria by high-speed counter current chromatography using stepwise elution. Analytical Instrumentation 2017(02): 24–29.
Wang, J.-W., Zhang, Y.-W., Li, X.-X., Li, L.-L., Wang, Y., Luo, X., Wang, L.-F., and Mao, X.-M. (2018). Extration and separation of okanin and its exploration antiplatelet aggregation effect. J. Xinjiang Med. Univ. 41: 1535–1538.
Wang, X.-Y., Su, J.-Q., Chu, X.-L., Zhang, X.-Y., Kan, Q.-B., Liu, R.-X., and Fu, X. (2021). Adsorption and Desorption Characteristics of Total Flavonoids from Acanthopanax senticosus on Macroporous Adsorption Resins. Molecules 26(14): 4162–4181.
Xiao, R., Zhan, L.-M., Gao, X.-X., Yan, L.-Y., Zhang, H., Zhu, Z.-Y., Wang, Q., and Jiang, D.-A. (2013). Separation and purification of flavonoid from Taxus remainder extracts free of taxoids using polystyrene and polyamide resin. J. Sep. Sci. 36: 1925–1934.
Xie, Y., Guo, Q.-S., and Wang, G.-S. (2016). Preparative separation and purification of the total flavonoids in Scorzonera austriaca with macroporous resins. Molecules 21(6): 768–779.
Xu, H., Li, R.-H., Xia, Y.-S., and Yang, X.-Q. (2021). Research status and prospect of extraction and purification methods of flavonoids. Appl. Chem. Industry 50(6): 1677–1682.
Xu, Y., Lv, X., Yang, G., Zhan, J., Li, M., Tao, L., Ho, C.-T., and Li, S. (2019). Simultaneous separation of six pure polymethoxyflavones from sweet orange peel extract by high performance counter current chromatography. Food Chem. 292: 160–165.
Yao, X., Li, X., Zhang, T., Ren, M., and Chen, W. (2016). Purification of total flavonoids from Xinjiang Coreopsis tinctoria Nutt. by using macroporous adsorptive resin. J. Liaojing Univ. TCM. 19(7): 60–63.
Yao, L., Zhang, Y.-J., Liu, J., Li, L.-L., Wang, Y., Lan, Y., and Mao, X.-M. (2017). Anti-inflammatory effect of extract of Coreopsis tinctoria Nutt. on high glucose-induced rat glomerular mesangial cell. J. Xinjiang Med. Univ. 40: 415–419.
Zain, M.S.C., Lee, S.Y., Teo, C.Y., Shaari, K., Santos-Buelga, C., and González-Paramás, A.M. (2020). Adsorption and desorption properties of total flavonoids from oil palm (Elaeis guineensis Jacq.) mature leaf on macroporous adsorption resins. Molecules 25(4): 1–17.
Zhang, C.-H., Qi, Y.-X., and Feng, X.-Q. (2019). Research advances on isolation and purification of flavonoids from Hippophea rhamnoides L. Storage and Process 19(4): 201–206.
Zhang, Y., Wang, J., Li, X., Li, L., Tao, Y., Luo, X., Wang, L., and Mao, X. (2020). Preparation of certified reference material and the homogeneity of flavanomarein and marein from Coreopsis tinctoria Nutt. J. Xinjiang Med. Univ. 43(3): 340–343.
京公网安备11010802044758号