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Review Article | Open Access

Research progress on the therapeutic effect of olfactory ensheathing cell transplantation on ischemic stroke

Jin Wang1Jianhua Zhao1( )Shaomin Li2
Henan Joint International Research Laboratory of Neurorestoratology for Senile Dementia, Henan Key Laboratory of Neurorestoratology, Department of Neurology, First Affiliated Hospital of Xinxiang Medical University, Xinxiang 453100, Henan, China
Ann Romney Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School, Boston 02115, Massachusetts, United States
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Olfactory ensheathing cells (OECs) are a special type of glial cell in the olfactory system, which exhibit neuroprotective, immunomodulatory, and angiogenic effects. Although many studies have focused on the reversal of demyelination and axonal degeneration (during spinal cord injury) by OECs, few reports have focused on the ability of OECs to repair ischemic nerve injury. This article reviews the protective effects of OEC transplantation in ischemic stroke and provides a theoretical basis and new strategy for OEC transplantation in the treatment of ischemic stroke.


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Journal of Neurorestoratology
Pages 83-93
Cite this article:
Wang J, Zhao J, Li S. Research progress on the therapeutic effect of olfactory ensheathing cell transplantation on ischemic stroke. Journal of Neurorestoratology, 2021, 9(2): 83-93.








Web of Science




Received: 15 May 2021
Revised: 16 June 2021
Accepted: 30 June 2021
Published: 05 June 2021
© The authors 2021

This article is published with open access at