References(46)
[1]
Donnelly DJ, Popovich PG. Inflammation and its role in neuroprotection, axonal regeneration and functional recovery after spinal cord injury. Exp Neurol. 2008, 209(2): 378-388.
[2]
Hohlfeld R, Kerschensteiner M, Meinl E. Dual role of inflammation in CNS disease. Neurology. 2007, 68(22 Suppl 3): S58-S63; discussion S91–6.
[3]
Kerschensteiner M, Gallmeier E, Behrens L, et al. Activated human T cells, B cells, and monocytes produce brain- derived neurotrophic factor in vitro and in inflammatory brain lesions: a neuroprotective role of inflammation? J Exp Med. 1999, 189(5): 865-870.
[4]
Yin YQ, Cui Q, Li YM, et al. Macrophage-derived factors stimulate optic nerve regeneration. J Neurosci. 2003, 23(6): 2284-2293.
[5]
Gordon S, Taylor PR. Monocyte and macrophage heterogeneity. Nat Rev Immunol. 2005, 5(12): 953-964.
[6]
Hu XM, Leak RK, Shi YJ, et al. Microglial and macrophage polarization—new prospects for brain repair. Nat Rev Neurol. 2015, 11(1): 56-64.
[7]
Kigerl KA, Gensel JC, Ankeny DP, et al. Identification of two distinct macrophage subsets with divergent effects causing either neurotoxicity or regeneration in the injured mouse spinal cord. J Neurosci. 2009, 29(43): 13435-13444.
[8]
Wake H, Moorhouse AJ, Nabekura J. Functions of microglia in the central nervous system——beyond the immune response. Neuron Glia Biol. 2011, 7(1): 47-53.
[9]
Perego C, Fumagalli S, Zanier ER, et al. Macrophages are essential for maintaining a M2 protective response early after ischemic brain injury. Neurobiol Dis. 2016, 96: 284-293.
[10]
London A, Cohen M, Schwartz M. Microglia and monocyte- derived macrophages: functionally distinct populations that act in concert in CNS plasticity and repair. Front Cell Neurosci. 2013, 7: 34.
[11]
Hu XM, Li PY, Guo YL, et al. Microglia/macrophage polarization dynamics reveal novel mechanism of injury expansion after focal cerebral ischemia. Stroke. 2012, 43(11): 3063-3070.
[12]
Sanberg PR, Park DH, Kuzmin-Nichols N, et al. Monocyte transplantation for neural and cardiovascular ischemia repair. J Cell Mol Med. 2010, 14(3): 553-563.
[13]
Chernykh ER, Shevela EY, Sakhno LV, et al. The generation and properties of human M2-like macrophages: Potential candidates for CNS repair? Cell Ther Transplant. 2010, 2(6): e.000080.01.
[14]
Sakhno LV, Shevela EY, Tikhonova MA, et al. The phenotypic and functional features of human M2 macrophages generated under low serum conditions. Scand J Immunol. 2016, 83(2): 151-159.
[15]
Chernykh ER, Shevela EY, Starostina NM, et al. Safety and therapeutic potential of M2-macrophages in stroke treatment. Cell Transplant. 2016, 25(8): 1461-1471.
[16]
Chernykh ER, Kafanova MY, Shevela EY, et al. Clinical experience with autologous M2 macrophages in children with severe cerebral palsy. Cell Transplant. 2014, 23(Suppl 1): S97-104.
[17]
Chernykh ER, Shevela EY, Kafanova MY, et al. Monocyte- derived macrophages for treatment of cerebral palsy: A study of 57 cases. J Neurorestoratology. 2018, 6: 41-47.
[18]
Dhuria SV, Hanson LR, Frey WH. Intranasal delivery to the central nervous system: mechanisms and experimental considerations. J Pharm Sci. 2010, 99(4): 1654-1673.
[19]
Galeano C, Qiu ZF, Mishra A, et al. The route by which intranasally delivered stem cells enter the central nervous system. Cell Transplant. 2018, 27(3): 501-514.
[20]
Alcalá-Barraza SR, Lee MS, Hanson LR, et al. Intranasal delivery of neurotrophic factors BDNF, CNTF, EPO and NT-4 to the CNS. J Drug Target. 2010, 18(3): 179-190.
[21]
Zhu JH, Jiang YJ, Xu GL, et al. Intranasal administration: a potential solution for cross-BBB delivering neurotrophic factors. Histol Histopathol. 2012, 27(5): 537-548.
[22]
Thorne RG, Pronk GJ, Padmanabhan V, et al. Delivery of insulin-like growth factor-I to the rat brain and spinal cord along olfactory and trigeminal pathways following intranasal administration. Neuroscience. 2004, 127(2): 481-496.
[23]
Dewji NN, Azar MR, Hanson LR, et al. Pharmacokinetics in rat of P8, a peptide drug candidate for the treatment of alzheimer’s disease: Stability and delivery to the brain1. ADR. 2018, 2(1): 169-179.
[24]
Benedict C, Kern W, Schultes B, et al. Differential sensitivity of men and women to anorexigenic and memory-improving effects of intranasal insulin. J Clin Endocrinol Metab. 2008, 93(4): 1339-1344.
[25]
Ashpole NM, Sanders JE, Hodges EL, et al. Growth hormone, insulin-like growth factor-1 and the aging brain. Exp Gerontol. 2015, 68: 76-81.
[26]
Crigler L, Robey RC, Asawachaicharn A, et al. Human mesenchymal stem cell subpopulations express a variety of neuro-regulatory molecules and promote neuronal cell survival and neuritogenesis. Exp Neurol. 2006, 198(1): 54-64.
[27]
Lu DY, Mahmood A, Qu CS, et al. Erythropoietin enhances neurogenesis and restores spatial memory in rats after traumatic brain injury. J Neurotrauma. 2005, 22(9): 1011-1017.
[28]
Yang XT, Bi YY, Feng DF. From the vascular microenvironment to neurogenesis. Brain Res Bull. 2011, 84(1): 1-7.
[29]
Chopp M, Li Y. Stimulation of plasticity and functional recovery after stroke- cell-based and pharmacological therapy. Eur Neurol Rev. 2011, 6(2): 97.
[30]
Gutiérrez-Fernández M, Fuentes B, Rodríguez-Frutos B, et al. Trophic factors and cell therapy to stimulate brain repair after ischaemic stroke. J Cell Mol Med. 2012, 16(10): 2280-2290.
[31]
Zhang ZG, Chopp M. Neurorestorative therapies for stroke: underlying mechanisms and translation to the clinic. Lancet Neurol. 2009, 8(5): 491-500.
[32]
Drago D, Cossetti C, Iraci N, et al. The stem cell secretome and its role in brain repair. Biochimie. 2013, 95(12): 2271-2285.
[33]
Ullah I, Chung K, Oh J, et al. Intranasal delivery of a Fas-blocking peptide attenuates Fas-mediated apoptosis in brain ischemia. Sci Rep. 2018, 8(1): 15041.
[34]
Zhang JY, Lee JH, Gu XH, et al. Intranasally delivered wnt3a improves functional recovery after traumatic brain injury by modulating autophagic, apoptotic, and regenerative pathways in the mouse brain. J Neurotrauma. 2018, 35(5): 802-813.
[35]
Nakamura T, Mizuno S. The discovery of hepatocyte growth factor (HGF) and its significance for cell biology, life sciences and clinical medicine. Proc Jpn Acad, Ser B, Phys Biol Sci. 2010, 86(6): 588-610.
[36]
Hamanoue M, Takemoto N, Matsumoto K, et al. Neurotrophic effect of hepatocyte growth factor on central nervous system neurons in vitro. J Neurosci Res. 1996, 43(5): 554-564.
[37]
Miyazawa T, Matsumoto K, Ohmichi H, et al. Protection of hippocampal neurons from ischemia-induced delayed neuronal death by hepatocyte growth factor: a novel neurotrophic factor. J Cereb Blood Flow Metab. 1998, 18(4): 345-348.
[38]
Bottaro DP, Rubin JS, Faletto DL, et al. Identification of the hepatocyte growth factor receptor as the c-met proto-oncogene product. Science. 1991, 251(4995): 802-804.
[39]
Shimamura M, Sato N, Waguri S, et al. Gene transfer of hepatocyte growth factor gene improves learning and memory in the chronic stage of cerebral infarction. Hypertension. 2006, 47(4): 742-751.
[40]
Wright JW, Harding JW. The brain hepatocyte growth factor/c-met receptor system: A new target for the treatment of Alzheimer's disease. J Alzheimers Dis. 2015, 45(4): 985-1000.
[41]
Wright JW, Kawas LH, Harding JW. The development of small molecule angiotensin IV analogs to treat Alzheimer’s and Parkinson’s diseases. Prog Neurobiol. 2015, 125: 26-46.
[42]
Shohayeb B, Diab M, Ahmed M, et al. Factors that influence adult neurogenesis as potential therapy. Transl Neurodegener. 2018, 7: 4.
[43]
Cai JY, Hua FZ, Yuan LH, et al. Potential therapeutic effects of neurotrophins for acute and chronic neurological diseases. Biomed Res Int. 2014, 2014: 601084.
[44]
Zhang XJ, Chen LW, Wang YZ, et al. Macrophage migration inhibitory factor promotes proliferation and neuronal differentiation of neural stem/precursor cells through Wnt/β-catenin signal pathway. Int J Biol Sci. 2013, 9(10): 1108-1120.
[45]
Conboy L, Varea E, Castro JE, et al. Macrophage migration inhibitory factor is critically involved in basal and fluoxetine-stimulated adult hippocampal cell proliferation and in anxiety, depression, and memory-related behaviors. Mol Psychiatry. 2011, 16(5): 533-547.
[46]
Ohta S, Misawa A, Fukaya R, et al. Macrophage migration inhibitory factor (MIF) promotes cell survival and proliferation of neural stem/progenitor cells. J Cell Sci. 2012, 125(Pt 13): 3210-3220.