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Brain Science Advances 2021, 7(2): 141-154 https://doi.org/10.26599/BSA.2021.9050015
Research Article | Open Access | Issue | Published: 05 June 2021

Quantitative analysis of cerebrovascular characteristics of Parkinson’s disease treated with acupuncture based on magnetic resonance angiography

Show Author's Information Yuan Yang1,  Le He2,  Suhua Miao1,  Rongsong Zhou1,  Yuqi Zhang1,  Yu Ma1( )
Tsinghua University Yuquan Hospital, Beijing 100040, China
Center for Biomedical Imaging Research, School of Medicine, Tsinghua University, Beijing 100084, China
Keywords:
acupuncture, Parkinson’s disease, magnetic resonance angiography, quantitative cerebrovascular characteristics, cerebral blood flow
Cite this article:
Yang Y, He L, Miao S, et al. Quantitative analysis of cerebrovascular characteristics of Parkinson’s disease treated with acupuncture based on magnetic resonance angiography. Brain Science Advances, 2021, 7(2): 141-154. https://doi.org/10.26599/BSA.2021.9050015
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Abstract Full text About this article
Background:

Acupuncture has become an important alternative clinical treatment for Parkinson’s disease (PD), but its efficacy and the underlying mechanisms remain debatable. Using a newly developed magnetic resonance angiography (MRA) method that has higher sensitivity for smaller and distal vessels and a novel tool that can trace vessels and extract vascular features, the immediate effects of acupuncture on intracranial vessels and blood flow in patients with PD as well as correlations with clinical outcomes were quantitatively evaluated.

Methods:

Fifteen PD patients received acupuncture at the Dazhui and Fengchi acupoint positions. MRA was performed before and after 30 min of treatment. The cerebral blood flow (CBF) and the length, volume, diameter, and signal intensity of the intracranial internal carotid artery (ICA) and middle cerebral artery (MCA) were measured. The Unified Parkinson’s Disease Rating Scale part III (UPDRS-III) and Visual Analogue Scale (VAS) were used to evaluate the motor symptoms and the subjective feelings of discomfort.

Results:

Acupuncture significantly reduced UPDRS-III and VAS scores. No significant changes were noted in the overall CBF before and after treatment. However, there was a significant extension effect on the length of the intracranial ICA and MCA and the distal MCA, and a significant increase in the number of branches of the MCA was found. Although acupuncture tended to increase the total volume of the intracranial ICA and the volume of the MCA, no statistical significance was reached. The total intensity was not altered, but the intensity and diameter of the M1 segment were significantly increased, whereas the intensity of the MCA was decreased. A positive correlation between M1 intensity changes and UPDRS-III changes was found.

Conclusions:

Angiographic evaluation suggested that acupuncture had a significant effect on intracranial blood vessels, which is one possible mechanism for acupuncture improving the motor symptoms of PD.


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About this article

Quantitative analysis of cerebrovascular characteristics of Parkinson’s disease treated with acupuncture based on magnetic resonance angiography

Show Author's information Yuan Yang1, Le He2, Suhua Miao1, Rongsong Zhou1, Yuqi Zhang1, Yu Ma1( )
Tsinghua University Yuquan Hospital, Beijing 100040, China
Center for Biomedical Imaging Research, School of Medicine, Tsinghua University, Beijing 100084, China

Abstract

Background:

Acupuncture has become an important alternative clinical treatment for Parkinson’s disease (PD), but its efficacy and the underlying mechanisms remain debatable. Using a newly developed magnetic resonance angiography (MRA) method that has higher sensitivity for smaller and distal vessels and a novel tool that can trace vessels and extract vascular features, the immediate effects of acupuncture on intracranial vessels and blood flow in patients with PD as well as correlations with clinical outcomes were quantitatively evaluated.

Methods:

Fifteen PD patients received acupuncture at the Dazhui and Fengchi acupoint positions. MRA was performed before and after 30 min of treatment. The cerebral blood flow (CBF) and the length, volume, diameter, and signal intensity of the intracranial internal carotid artery (ICA) and middle cerebral artery (MCA) were measured. The Unified Parkinson’s Disease Rating Scale part III (UPDRS-III) and Visual Analogue Scale (VAS) were used to evaluate the motor symptoms and the subjective feelings of discomfort.

Results:

Acupuncture significantly reduced UPDRS-III and VAS scores. No significant changes were noted in the overall CBF before and after treatment. However, there was a significant extension effect on the length of the intracranial ICA and MCA and the distal MCA, and a significant increase in the number of branches of the MCA was found. Although acupuncture tended to increase the total volume of the intracranial ICA and the volume of the MCA, no statistical significance was reached. The total intensity was not altered, but the intensity and diameter of the M1 segment were significantly increased, whereas the intensity of the MCA was decreased. A positive correlation between M1 intensity changes and UPDRS-III changes was found.

Conclusions:

Angiographic evaluation suggested that acupuncture had a significant effect on intracranial blood vessels, which is one possible mechanism for acupuncture improving the motor symptoms of PD.

Keywords: acupuncture, Parkinson’s disease, magnetic resonance angiography, quantitative cerebrovascular characteristics, cerebral blood flow

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Received: 25 March 2021
Revised: 15 June 2021
Accepted: 21 June 2021
Published: 05 June 2021
Issue date: June 2021

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© The authors 2021

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