AI Chat Paper
Discover the SciOpen Platform and Achieve Your Research Goals with Ease.
Search articles, authors, keywords, DOl and etc.
{{expandStatus?'Exit ':''}}Advanced Search
The aging population is an important issue around the world especially in developed countries. Although medical advances have substantially extended life span, the same cannot be said for the duration of health span. We are seeing increasing numbers of elderly people who are frail and/or have multiple chronic conditions; all of these can affect the quality of life of the elderly population as well as increase the burden on the healthcare system. Aging is mechanistically related to common medical conditions such as diabetes mellitus, ischemic heart disease, cognitive decline, and frailty. A recently accepted concept termed ‘Accelerated Biological Aging’ can be diagnosed when a person’s biological age—as measured by biomarkers of DNA methylation—is older than their corresponding chronological age. Taurine, a conditionally essential amino acid, has received much attention in the past few years. A substantial number of animal studies have provided a strong scientific foundation suggesting that this amino acid can improve cellular and metabolic health, including blood glucose control, so much that it has been labelled one of the ‘longevity amino acids’. In this review article, we propose the rationale that an adequately powered randomized-controlled-trial (RCT) is needed to confirm whether taurine can meaningfully improve metabolic and microbiome health, and biological age. This trial should incorporate certain elements in order to provide the much-needed evidence to guide doctors, and also the community at large, to determine whether this promising and inexpensive amino acid is useful in improving human metabolic health.
Partridge L, Deelen J Slagboom PE. Facing up to the global challenges of ageing. Nature 2018; 561: 45−56.
Ji L, Jazwinski SM, Kim S. Frailty and biological age. Ann Geriatr Med Res 2021; 25: 141−149.
Nachun D, Lu AT, Bick AG, et al. NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium. Clonal hematopoiesis associated with epigenetic aging and clinical outcomes. Aging Cell 2021; 20: e13366.
Taylor RC, Hetz C. Mastering organismal aging through the endoplasmic reticulum proteostasis network. Aging Cell 2020; 19: e13265.
Zhang B, Trapp A, Kerepesi C, Gladyshev VN. Emerging rejuvenation strategies-Reducing the biological age. Aging Cell 2022; 21: e13538.
Schmitz LL, Zhao W, Ratliff SM, et al. The Socioeconomic Gradient in Epigenetic Ageing Clocks: Evidence from the Multi-Ethnic Study of Atherosclerosis and the Health and Retirement Study. Epigenetics 2022; 17: 589−611.
Levine ME, Lu AT, Quach A, et al. An epigenetic biomarker of aging for lifespan and healthspan. Aging (Albany NY) 2018; 10: 573−591.
Liu Z, Kuo PL, Horvath S, et al. A new aging measure captures morbidity and mortality risk across diverse subpopulations from NHANES IV: A cohort study. PLoS Med 2018; 15: e1002718.
Ho KM. Biological age as a predictor of unplanned intensive care readmission during the same hospitalization. Heart Lung 2023; 62: 249−255.
Yi M, Zhang W, Zhang X, et al. The effectiveness of Otago exercise program in older adults with frailty or pre-frailty: A systematic review and meta-analysis. Arch Gerontol Geriatr 2023; 114: 105083.
Lohman T, Bains G, Cole S, et al. High-Intensity interval training reduces transcriptomic age: A randomized controlled trial. Aging Cell 2023; 22: e13841.
Fitzgerald KN, Campbell T, Makarem S, Hodges R. Potential reversal of biological age in women following an 8-week methylation-supportive diet and lifestyle program: a case series. Aging (Albany NY) 2023; 15: 1833−1839.
Ho E, Qualls C, Villareal DT. Effect of diet, exercise, or both on biological age and healthy aging in older adults with obesity: secondary analysis of a randomized controlled trial. J Nutr Health Aging 2022; 26: 552−557.
Memelink RG, Hummel M, Hijlkema A, et al. Additional effects of exercise to hypocaloric diet on body weight, body composition, glycaemic control and cardio-respiratory fitness in adults with overweight or obesity and type 2 diabetes: A systematic review and meta-analysis. Diabet Med 2023; 40: e15096.
Ames BN. Prolonging healthy aging: Longevity vitamins and proteins. Proc Natl Acad Sci U S A 2018; 115: 10836−10844.
Oja SS, Saransaari P. Taurine and the Brain. Adv Exp Med Biol 2022; 1370: 325−331.
Singh P, Gollapalli K, Mangiola S, et al. Taurine deficiency as a driver of aging. Science 2023; 380: eabn9257.
Beutner F, Ritter C, Scholz M, et al. A metabolomic approach to identify the link between sports activity and atheroprotection. Eur J Prev Cardiol 2022; 29(): 436−444.
Schuit FC, Kiekens R, Pipeleers DG. Measuring the balance between insulin synthesis and insulin release. Biochem Biophys Res Commun 1991; 178: 1182−1187.
Sharma RB, Landa-Galván HV, Alonso LC. Living dangerously: protective and harmful er stress responses in pancreatic β-cells. Diabetes 2021; 70: 2431−2443.
Zhao D, Zhang X, Bian Y, et al. Taurine reduces apoptosis mediated by endoplasmic reticulum stress in islet β-cells induced by high-fat and -glucose diets. Food Chem Toxicol 2023; 175: 113700.
Sarnobat D, Moffett RC, Ma J, et al. Taurine rescues pancreatic β-cell stress by stimulating α-cell transdifferentiation. Biofactors 2023; 49: 646−662.
Lee JH, Lee JH, Rane SG. TGF-β signalling in pancreatic islet β cell development and function. Endocrinology 2021; 162: bqaa233.
Schaffer S, Kim HW. Effects and mechanisms of taurine as a therapeutic agent. Biomol Ther (Seoul) 2018; 26: 225−241.
Pérez-Hernández E, Pastrana-Carballo JJ, Gómez-Chávez F, et al. A key metabolic regulator of bone and cartilage health. Endocrinol Metab (Seoul) 2022; 37: 559−574.
Tao X, Zhang Z, Yang Z, Rao B. The effects of taurine supplementation on diabetes mellitus in humans: A systematic review and meta-analysis. Food Chem (Oxf) 2022; 4: 100106.
Page LK, Jeffries O, Waldron M. Acute taurine supplementation enhances thermoregulation and endurance cycling performance in the heat. Eur J Sport Sci 2019; 19: 1101−1109.
Azuma J, Sawamura A, Awata N. Usefulness of taurine in chronic congestive heart failure and its prospective application. Jpn Circ J 1992; 56: 95−99.
Chakraborty S, Lulla A, Cheng X, et al. Conjugated bile acids are nutritionally re-programmable antihypertensive metabolites. J Hypertens 2023; 41: 979−994.
Zangerolamo L, Carvalho M, Barssotti L, et al. The bile acid TUDCA reduces age-related hyperinsulinemia in mice. Sci Rep 2022; 12: 22273.
Duszka K. Versatile triad alliance: bile acid, taurine and microbiota. Cells 2022; 11: 2337.
Freitas IN, da Silva JA Jr, de Oliveira KM, et al. Insights by which TUDCA is a potential therapy against adiposity. Front Endocrinol (Lausanne) 2023; 14: 1090039.
Christiansen CB, Trammell SAJ, Wewer Albrechtsen NJ, et al. Bile acids drive colonic secretion of glucagon-like-peptide 1 and peptide-YY in rodents. Am J Physiol Gastrointest Liver Physiol 2019; 316: G574−G584.
Reilly SJ, O'Shea EM, Andersson U, et al. A peroxisomal acyltransferase in mouse identifies a novel pathway for taurine conjugation of fatty acids. FASEB J 2007; 21: 99−107.
Grevengoed TJ, Trammell SAJ, McKinney MK, et al. N-acyl taurines are endogenous lipid messengers that improve glucose homeostasis. Proc Natl Acad Sci U S A 2019; 116(49): 24770−24778.
Viljoen A, Bain SC. Glucagon-like peptide 1 therapy: from discovery to type 2 diabetes and beyond. Endocrinol Metab (Seoul) 2023; 38: 25−33.
Gribble FM, Reimann F. Metabolic messengers: glucagon-like peptide 1. Nat Metab 2021; 3: 142−148.
da Silva Junior JA, Ribeiro RA. Potential binding sites for taurine on the insulin receptor: a molecular docking study. Adv Exp Med Biol 2022; 1370: 257−266.
da Silva JA Jr, Figueiredo LS, Chaves JO, et al. Effects of tauroursodeoxycholic acid on glucose homeostasis: Potential binding of this bile acid with the insulin receptor. Life Sci 2021; 285: 120020.
Jeong JK, Horwath JA, Simonyan H, et al. Subfornical organ insulin receptors tonically modulate cardiovascular and metabolic function. Physiol Genomics 2019; 51: 333−341.
Wang Z, Ohata Y, Watanabe Y, et al. Taurine improves lipid metabolism and increases resistance to oxidative stress. J Nutr Sci Vitaminol (Tokyo) 2020; 66: 347−356.
Gregor A, Pignitter M, Fahrngruber C, et al. Caloric restriction increases levels of taurine in the intestine and stimulates taurine uptake by conjugation to glutathione. J Nutr Biochem 2021; 96: 108781.
Gregor A, Pignitter M, Trajanoski S, et al. Microbial contribution to the caloric restriction-triggered regulation of the intestinal levels of glutathione transferases, taurine, and bile acid. Gut Microbes 2021; 13: 1992236.
Laiteerapong N, Ham SA, Gao Y, et al. The Legacy effect in type 2 diabetes: impact of early glycemic control on future complications (the diabetes & aging study). Diabetes Care 2019; 42: 416−426.
Schöttker B, Rathmann W, Herder C, et al. HbA1c levels in non-diabetic older adults - No J-shaped associations with primary cardiovascular events, cardiovascular and all-cause mortality after adjustment for confounders in a meta-analysis of individual participant data from six cohort studies. BMC Med 2016; 14: 26.
Li C, Zhou Y, Niu Y, et al. Deficiency of Pdk1 drives heart failure by impairing taurine homeostasis through Slc6a6. FASEB J 2023; 37: e23134.
Beyranvand MR, Khalafi MK, Roshan VD, et al. Effect of taurine supplementation on exercise capacity of patients with heart failure. J Cardiol 2011; 57: 333−337.
Razzaghi A, Choobineh S, Gaeini A, Soori R. Interaction of exercise training with taurine attenuates infarct size and cardiac dysfunction via Akt-Foxo3a-Caspase-8 signaling pathway. Amino Acids 2023; 55: 869−880.
Ahmadian M, Dabidi Roshan V, Ashourpore E. Taurine supplementation improves functional capacity, myocardial oxygen consumption, and electrical activity in heart failure. J Diet Suppl 2017; 14: 422−432.
Milei J, Ferreira R, Llesuy S, et al. Reduction of reperfusion injury with preoperative rapid intravenous infusion of taurine during myocardial revascularization. Am Heart J 1992; 123: 339−345.
Díaz HS, Andrade DC, Toledo C, et al. Inhibition of brainstem endoplasmic reticulum stress rescues cardiorespiratory dysfunction in high output heart failure. Hypertension 2021; 77: 718−728.
Sun Q, Wang B, Li Y, et al. Taurine supplementation lowers blood pressure and improves vascular function in prehypertension: randomized, double-blind, placebo-controlled study. Hypertension 2016; 67: 541−549.
Yang JY, Zhang TT, Yu ZL, et al. Taurine alleviates trimethylamine n-oxide-induced atherosclerosis by regulating bile acid metabolism in ApoE-/- Mice. J Agric Food Chem 2022; 70: 5738−5747.
Maleki V, Alizadeh M, Esmaeili F, Mahdavi R. The effects of taurine supplementation on glycemic control and serum lipid profile in patients with type 2 diabetes: a randomized, double-blind, placebo-controlled trial. Amino Acids 2020; 52: 905−914.
Haidari F, Asadi M, Mohammadi-Asl J, Ahmadi-Angali K. Effect of weight-loss diet combined with taurine supplementation on body composition and some biochemical markers in obese women: a randomized clinical trial. Amino Acids 2020; 52: 1115−1124.
Kopin L, Lowenstein C. Dyslipidemia. Ann Intern Med 2017; 167: ITC81−ITC96.
Yamori Y, Taguchi T, Hamada A, et al. Taurine in health and diseases: consistent evidence from experimental and epidemiological studies. J Biomed Sci 2010; 17(Suppl 1): S6.
Sun S, He D, Luo C, et al. Metabolic syndrome and its components are associated with altered amino acid profile in Chinese Han population. Front Endocrinol (Lausanne) 2022; 12: 795044.
Shearrer GE. The interaction of glycemia with anxiety and depression is related to altered cerebellar and cerebral functional correlations. Brain Sci 2023; 13: 1086.
Wu G, Zhou J, Yang M, et al. The Regulatory Effects of taurine on neurogenesis and apoptosis of neural stem cells in the hippocampus of rats. Adv Exp Med Biol 2022; 1370: 351−367.
Zhu Y, Wang R, Fan Z, et al. Taurine alleviates chronic social defeat stress-induced depression by protecting cortical neurons from dendritic spine loss. Cell Mol Neurobiol 2023; 43: 827−840.
Moludi J, Qaisar SA, Kadhim MM, et al. Protective and therapeutic effectiveness of taurine supplementation plus low calorie diet on metabolic parameters and endothelial markers in patients with diabetes mellitus: a randomized, clinical trial. Nutr Metab (Lond) 2022; 19(1): 49.
Ma CC, Butler D, Milligan V, et al. Continuous process for the production of taurine from monoethanolamine. Ind Eng Chem Res 2020; 59: 13007−13015.
Rios LP, Ye C, Thabane L. Association between framing of the research question using the PICOT format and reporting quality of randomized controlled trials. BMC Med Res Methodol 2010; 10: 11.
Sak D, Erdenen F, Müderrisoglu C, et al. The relationship between plasma taurine levels and diabetic complications in patients with type 2 diabetes mellitus. Biomolecules 2019; 9(3): 96.
Merheb M, Daher RT, Nasrallah M, et al. Taurine intestinal absorption and renal excretion test in diabetic patients: a pilot study. Diabetes Care 2007; 30: 2652−2654.
Zheng Y, Ceglarek U, Huang T, et al. Plasma taurine, diabetes genetic predisposition, and changes of insulin sensitivity in response to weight-loss diets. J Clin Endocrinol Metab 2016; 101: 3820−3826.
Discacciati A, Bellavia A, Lee JJ, et al. Med4way: a Stata command to investigate mediating and interactive mechanisms using the four-way effect decomposition. Int J Epidemiol 2019; 48: 15−20.
Suliman ME, Bárány P, Filho JC, et al. Accumulation of taurine in patients with renal failure. Nephrol Dial Transplant 2002; 17: 528−529.
Roşca AE, Vlădăreanu AM, Mirica R, et al. Taurine and its derivatives: analysis of the inhibitory effect on platelet function and their antithrombotic potential. J Clin Med 2022; 11: 666.
Santulli G, Kansakar U, Varzideh F, et al. Functional Role of Taurine in Aging and Cardiovascular Health: An Updated Overview. Nutrients 2023; 15: 4236.
Akselrod D, Friger M, Biderman A. HbA1C variability among type 2 diabetic patients: a retrospective cohort study. Diabetol Metab Syndr 2021; 13: 101.
Riedel B, Li MH, Lee CHA, et al; METS Study Investigators. A simplified (modified) Duke Activity Status Index (M-DASI) to characterise functional capacity: a secondary analysis of the Measurement of Exercise Tolerance before Surgery (METS) study. Br J Anaesth 2021; 126: 181−190.
Canada JM, Reynolds MA, Myers R, et al. Usefulness of the Duke activity status index to select an optimal cardiovascular exercise stress test protocol. Am J Cardiol 2021; 146: 107−114.
Du X, Liao J, Ye Q, Wu H. Multidimensional internet use, social participation, and depression among middle-aged and elderly Chinese individuals: nationwide cross-sectional study. J Med Internet Res 2023; 25: e44514.
Cleland C, Ferguson S, Ellis G, Hunter RF. Validity of the International Physical Activity Questionnaire (IPAQ) for assessing moderate-to-vigorous physical activity and sedentary behaviour of older adults in the United Kingdom. BMC Med Res Methodol 2018; 18: 176.
Miyata M, Tanaka T, Takahashi K, et al. Cholesterol-lowering effects of taurine through the reduction of ileal FXR signalling due to the alteration of ileal bile acid composition. Amino Acids 2021; 53: 1523−1532.
Liu H, Inoue R, Koyanagi M, et al. Potential effects of alpha-glycosyl isoquercitrin on memory by altering the gut microbiota-blood-brain axis in mice. J Agric Food Chem 2023; 71: 15991−16002.
Havel PJ, Kievit P, Comuzzie AG, Bremer AA. Use and importance of nonhuman primates in metabolic disease research: current state of the field. ILAR J 2017; 58: 251−268.
1697
Views
248
Downloads
1
Crossref
0
Web of Science
0
Scopus
0
CSCD
Altmetrics
京公网安备11010802044758号