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Background:

The purpose of this study was to evaluate the pattern of bone loss and its consequences in a group of spinal cord injury (SCI) patients managed at the Spinal Unit-Royal Rehabilitation Centre, King Hussein Medical Centre, and its correlation with level and extent of injury, age, and time since injury.

Methods:

Bone mineral density (BMD) was measured by dual energy x-ray absorptiometry at the lumbar spine and femoral neck in a group of patients who had suffered an SCI a mean of 8.6 (range 1–31) years earlier and had completed their medical and rehabilitation program during the period July 2003 to December 2013. The patients were diagnosed to have osteoporosis according to World Health Organization criteria and their fracture risk was estimated from this score using published data. The severity of their spinal injuries ranged from class A to D according to American Spinal Injury Association criteria.

Results:

Of the 55 patients included in the study, 45 were male and ten were female, with a male to female ratio of 4.5:1. Their mean age was 39.5 (range 13–61) years. Bone loss indicated by low BMD revealed that the femoral region was predominantly affected, with relative preservation of the lumbar spine. Abnormal BMD values were detected in 83.6% of subjects, and fractures occurred in 16.4% following minor trauma. A positive correlation was noted between time since injury and degree of osteoporosis. Individuals with complete lesions showed lower BMD values than those with incomplete lesions. No significant correlation was found with age or sex.

Conclusion:

SCI patients are at high risk of developing osteoporosis, which can lead to significant morbidity, particularly lower extremity fractures without significant trauma. Prevention and early treatment of bone loss are important in this patient group to avoid further functional impairment.


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Bone loss following spinal cord injury

Show Author's information Ali H Otom( )M Rami Al-Ahmar
Rheumatology and Rehabilitation Department, Royal Rehabilitation Centre, King Hussein Medical Centre, Amman, Jordan

Abstract

Background:

The purpose of this study was to evaluate the pattern of bone loss and its consequences in a group of spinal cord injury (SCI) patients managed at the Spinal Unit-Royal Rehabilitation Centre, King Hussein Medical Centre, and its correlation with level and extent of injury, age, and time since injury.

Methods:

Bone mineral density (BMD) was measured by dual energy x-ray absorptiometry at the lumbar spine and femoral neck in a group of patients who had suffered an SCI a mean of 8.6 (range 1–31) years earlier and had completed their medical and rehabilitation program during the period July 2003 to December 2013. The patients were diagnosed to have osteoporosis according to World Health Organization criteria and their fracture risk was estimated from this score using published data. The severity of their spinal injuries ranged from class A to D according to American Spinal Injury Association criteria.

Results:

Of the 55 patients included in the study, 45 were male and ten were female, with a male to female ratio of 4.5:1. Their mean age was 39.5 (range 13–61) years. Bone loss indicated by low BMD revealed that the femoral region was predominantly affected, with relative preservation of the lumbar spine. Abnormal BMD values were detected in 83.6% of subjects, and fractures occurred in 16.4% following minor trauma. A positive correlation was noted between time since injury and degree of osteoporosis. Individuals with complete lesions showed lower BMD values than those with incomplete lesions. No significant correlation was found with age or sex.

Conclusion:

SCI patients are at high risk of developing osteoporosis, which can lead to significant morbidity, particularly lower extremity fractures without significant trauma. Prevention and early treatment of bone loss are important in this patient group to avoid further functional impairment.

Keywords: spinal cord injury, bone loss, bone mineral density, osteoporosis, American Spinal Injury Association

References(23)

1.
Goddard D, Kleerekoper M. The epidemiology of osteoporosis. Postgrad Med. 1998;104:54–72.
2.
Gerland DE, Stewart CA, Adkins RH, et al. Osteoporosis after spinal cord injury. J Orthop Res. 1992;10:371–378.
3.
Demirel G, Yilmaz H, Paker N, Onel S. Osteoporosis after spinal cord injury. Spinal Cord. 1998;36:822–825.
4.
Jiang S-D, Dai L-Y, Jiang L-S. Osteoporosis after spinal cord injury. Osteoporos Int. 2006;17:180–192.
5.
Yilmaz B, Yasar E, Goktepe AS, et al. The relationship between basal metabolic rate and femur bone mineral density in men with traumatic spinal cord injury. Arch Phys Med Rehabil. 2007;88:758–761.
6.
Voor MJ, Brown EH, Xu Q, et al. Bone loss following spinal cord injury in a rat model. J Neurotrauma. 2012;29:1676–1682.
7.
Weiss D, Yada R, Talaver F, Foye P. Osteoporosis and spinal cord injury. Available from: http://emedicine.medscape.com/article/322204-overview. Accessed April 21, 2014.
8.
Kaplan PE, Roden W, Gilbert E, Richards L, Goldschmidt J. Reduction of hypercalciuria in tetraplegia after weight-bearing and strengthening exercises. Paraplegia. 1981;19:289–293.
9.
Claus-Walker J, Carter RE, Compos RJ, Spencer WA. Hypercalcemia in early traumatic quadriplegia. J Chronic Dis. 1975;28:81–90.
10.
Otom A, Al-Ahmar MR. Osteoporosis following spinal cord injury. Journal of the Royal Medical Services. 2012;19:68–71.
11.
American Spinal Injury Association. International Standards for Neurological Classification of Spinal Cord Injury. Revised 2002. Chicago, IL, USA: American Spinal Injury Association; 2006.
12.
World Health Organization, National Osteoporosis Foundation. Clinician’s Guide to Prevention and Treatment of Osteoporosis. Geneva, Switzerland: World Health Organization; 2010.
13.
Pedrera JD, Manas P, Gomez MA, et al. Ultrasound bone mass in paraplegic patients. Spinal Cord. 2002;40:83–87.
14.
Ryan PJ. Overview of role of BMD measurements in managing osteoporosis. Semin Nucl Med. 1997;27:197–207.
15.
Wilmet E, Ismail AA, Heilporn A, Welraeds D, Bergmann P. Longitudinal study of the bone mineral content and soft tissue composition after spinal cord section. Paraplegia. 1995;33:674–677.
16.
Szollar SM, Martin EM, Sartoris DJ, Parthemore JG, Deftos LJ. Bone mineral density and indexes of bone metabolism in spinal cord injury. Am J Phys Med Rehabil. 1998;77:28–35.
17.
Vestergaard P, Krogh K, Rejnmark L, Mosekilde L. Fracture rates and risk factors for fractures in patient with spinal injury. Spinal Cord. 1998;36:790–796.
18.
Dudley-Javoroski S, Shields RK. Regional cortical and trabecular bone loss after spinal cord injury. J Rehabil Res Dev. 2012;49: 1365–1376.
19.
Ragnarsson KT, Sell GH. Lower extremity fractures after spinal cord injury. Arch Phys Med Rehabil. 1981;62:418–423.
20.
Lazo MG, Shirazi P, Sam M, Giobbie-Hurder A, Blacconiere MJ, Muppidi M. Osteoprosis and risk of fracture in men with spinal cord injury. Spinal Cord. 2001;39:208–214.
21.
Biering-Sorensen F, Bohr H, Schaadt O. Bone mineral content of the lumbar spine and lower extremities years after spinal cord lesion. Paraplegia. 1988;26:293–301.
22.
Geomaere S, Van Learem, De Neve P, Kaufman JM. Bone mineral status in paraplegic patients who do or do not perform standing. Osteoporos Int. 1994;4:138–143.
23.
Fattal C, Mariano-Goulart D, Thomas E, Rouays-Mabit H, Verollet C, Maimoun L. Osteoporosis in persons with spinal cord injury: the need for a targeted therapeutic education. Arch Phys Med Rehabil. 2011;92: 59–67.
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Published: 23 May 2014
Issue date: December 2014

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© 2014 The Author(s).

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© 2014 Otom and Al-Ahmar. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License. The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. Permissions beyond the scope of the License are administered by Dove Medical Press Limited. Information on how to request permission may be found at: http://www.dovepress.com/permissions.php

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