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Journal of Neurorestoratology 2014, 2(1): 1-14 https://doi.org/10.2147/JN.S49206
Review | Open Access | Issue | Published: 06 December 2013

Molecular and structural bases for postsynaptic signal processing: interaction between postsynaptic density and postsynaptic membrane rafts

Show Author's Information Tatsuo Suzuki1( ),  Wei-Dong Yao2
Department of Neuroplasticity, Shinshu University Graduate School of Medicine, Matsumoto, Japan
Department of Psychiatry, Beth Israel Deaconess Medical Center, and Division of Neuroscience, New England Primate Research Center, Harvard Medical School, Southborough, MA, USA
Keywords:
synaptic plasticity, synaptogenesis, postsynaptic density, postsynaptic membrane raft, synaptic structure
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Suzuki T, Yao W-D. Molecular and structural bases for postsynaptic signal processing: interaction between postsynaptic density and postsynaptic membrane rafts. Journal of Neurorestoratology, 2014, 2(1): 1-14. https://doi.org/10.2147/JN.S49206
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Abstract Full text About this article

Postsynaptic membrane rafts (or lipid rafts) (PSRs), together with the postsynaptic density (PSD), are believed to be major sites important for postsynaptic signaling, function, and plasticity. Although the PSD has received much attention and is extensively investigated, PSR roles and their relationship with PSDs are poorly understood. Our recent work has identified PSD–PSR complexes from synaptic membranes of the rat brain and demonstrated specific interactions between them in vitro. Here, we review recent progress in this field, focusing on the molecular identities of the PSR, its biochemical purification, and its potential roles in postsynaptic signaling, function, and plasticity via cross talk with the PSD. We propose that the PSR and PSD are two major postsynaptic signaling domains that interact physiologically, and that PSRs are indispensable to PSD functions. Roles of PSRs in synaptogenesis, growth, and maturation of developing PSDs, and support and regulation of functions and plasticity of mature PSDs are discussed.


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About this article

Molecular and structural bases for postsynaptic signal processing: interaction between postsynaptic density and postsynaptic membrane rafts

Show Author's information Tatsuo Suzuki1( ), Wei-Dong Yao2
Department of Neuroplasticity, Shinshu University Graduate School of Medicine, Matsumoto, Japan
Department of Psychiatry, Beth Israel Deaconess Medical Center, and Division of Neuroscience, New England Primate Research Center, Harvard Medical School, Southborough, MA, USA

Abstract

Postsynaptic membrane rafts (or lipid rafts) (PSRs), together with the postsynaptic density (PSD), are believed to be major sites important for postsynaptic signaling, function, and plasticity. Although the PSD has received much attention and is extensively investigated, PSR roles and their relationship with PSDs are poorly understood. Our recent work has identified PSD–PSR complexes from synaptic membranes of the rat brain and demonstrated specific interactions between them in vitro. Here, we review recent progress in this field, focusing on the molecular identities of the PSR, its biochemical purification, and its potential roles in postsynaptic signaling, function, and plasticity via cross talk with the PSD. We propose that the PSR and PSD are two major postsynaptic signaling domains that interact physiologically, and that PSRs are indispensable to PSD functions. Roles of PSRs in synaptogenesis, growth, and maturation of developing PSDs, and support and regulation of functions and plasticity of mature PSDs are discussed.

Keywords: synaptic plasticity, synaptogenesis, postsynaptic density, postsynaptic membrane raft, synaptic structure

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Published: 06 December 2013
Issue date: December 2014

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© 2014 The Author(s).

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© 2014 Suzuki and Yao. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License. The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. Permissions beyond the scope of the License are administered by Dove Medical Press Limited. Information on how to request permission may be found at: http://www.dovepress.com/permissions.php

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