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Original Article | Open Access

Repairing skull defects in children with nano-hap/collagen composites: A clinical report of thirteen cases

Tuoyu Chen1, Yuqi Zhang1( ), Huancong Zuo1, Yapeng Zhao3, Chaoqiang Xue1, Bin Luo1, Qinglin Zhang1, Jin Zhu1, Xiumei Wang2, Fuzhai Cui2
Department of Neurosurgery, Tsinghua University Yuquan Hospital, Beijing 100040, China
School of Materials Science and Engineering, Tsinghua University, Beijing 100084, China
The Medical Center, Tsinghua University, Beijing 100084, China
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Abstract

Objective:

To evaluate the clinical results of repairing skull defects with biomimetic bone (nano-hap/collagen composites, NHACs) in children.

Methods:

Thirteen children with skull defects were treated with NHACs in our hospital. The NHACs molded with the help of a 3D printer were used in the operations.

Results:

All 13 operations were successful, and patients recovered without infection. Only one patient suffered from subcutaneous hydrops post-operation. The implanted NHACs remained fixed well after 1 year, and their CT HU values raised gradually. Skull shapes of children developed normally. Recovery of neurological and cognitive function was significant.

Conclusions:

NHAC, chosen to repair skull defects in children, can coexist with normal skull and reduce the negative effects on growth and development. NHAC could be a good choice for children with skull defects.

Keywords

cranioplastychildrenbiomimetic bone3D printing

References

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Brain Science Advances
Volume 2 Issue 1,
March 2016
Pages 31-37
DOI: 10.18679/CN11-6030_R.2016.005

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Cite this article:
Chen T, Zhang Y, Zuo H, et al. Repairing skull defects in children with nano-hap/collagen composites: A clinical report of thirteen cases. Brain Science Advances, 2016, 2(1): 31-37. https://doi.org/10.18679/CN11-6030_R.2016.005

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Received: 05 January 2016
Revised: 02 February 2016
Accepted: 05 February 2016
Published: 01 March 2016
© The authors 2016.

This article is published with open access at www.TNCjournal.com