Morphological predictors of posterior communicating artery aneurysms rupture

Nan Lv; Yibin Fang; Ying Yu; Jinyu Xu; Jianmin Liu; Qinghai Huang

doi:10.18679/CN11-6030_R.2015.010

Brain Science Advances 2015, 1(2): 86-91 https://doi.org/10.18679/CN11-6030_R.2015.010

Research Article |

Open Access | Issue | Published: 01 December 2015

Morphological predictors of posterior communicating artery aneurysms rupture

Show Author's Information Hide Author's Information Nan Lv, Yibin Fang, Ying Yu, Jinyu Xu, Jianmin Liu, Qinghai Huang(

)

Department of Neurosurgery, Changhai Hospital, Second Military Medical University, Shanghai 200433, China

Keywords:

morphology, intracranial aneurysm, posterior communicating artery, rupture

Cite this article:

Lv N, Fang Y, Yu Y, et al. Morphological predictors of posterior communicating artery aneurysms rupture. Brain Science Advances, 2015, 1(2): 86-91. https://doi.org/10.18679/CN11-6030_R.2015.010

Download citation

EndNote(RIS)

BibTeX

310

Views

Downloads

Citations

Crossref

N/A

WoS

N/A

Scopus

N/A

CSCD

Abstract Full text About this article

Abstract

Objective:

The conflicting findings of previous morphological studies on intracranial aneurysm rupture may be caused by the different locations of aneurysms. We aimed to determine the independent risk factors of aneurysm rupture by focusing on only posterior communicating artery (PcomA) aneurysms.

Methods:

In 89 PcomA aneurysms (58 ruptured, 31 unruptured), clinical and morphological characteristics were compared between the ruptured and unruptured groups. Multivariate logistic regression analysis was performed to determine the independent predictors for the rupture status of PcomA aneurysms.

Results:

In univariate analyses, the aneurysm dome size, aspect ratio, size ratio, dome-to-neck ratio, and inflow angle were significant parameters. With multivariate analyses, only the aneurysm dome size and inflow angle were significantly associated with the rupture status of PcomA aneurysms.

Conclusions:

Morphology was related with rupture of PcomA aneurysms. The aneurysm dome size and inflow angle were found to be the independent parameters characterizing the rupture status of PcomA aneurysms.

Full text

Abstract

Full text

Outline

About this article

Morphological predictors of posterior communicating artery aneurysms rupture

Show Author's information Hide Author's Information Nan Lv, Yibin Fang, Ying Yu, Jinyu Xu, Jianmin Liu, Qinghai Huang(

)

Department of Neurosurgery, Changhai Hospital, Second Military Medical University, Shanghai 200433, China

Abstract

Objective:

Methods:

Results:

Conclusions:

Morphology was related with rupture of PcomA aneurysms. The aneurysm dome size and inflow angle were found to be the independent parameters characterizing the rupture status of PcomA aneurysms.

Keywords: morphology, intracranial aneurysm, posterior communicating artery, rupture

References(18)

[1]

Korja M, Lehto H, Juvela S. Lifelong rupture risk of intracranial aneurysms depends on risk factors: A prospective Finnish cohort study. Stroke 2014, 45(7): 1958-1963.

DOI Google Scholar

[2]

Morita A, Kirino T, Hashi K, Aoki N, Fukuhara S, Hashimoto N, Takeo N, Sakai M, Teramoto A, Tominari S, Yoshimoto T. The natural course of unruptured cerebral aneurysms in a Japanese cohort. N Engl J Med 2012, 366(26): 2474-2482.

DOI Google Scholar

[3]

Bor ASE, Tiel Groenestege AT, terBrugge KG, Agid R, Velthuis BK, Rinkel GJE, Wermer MJH. Clinical, radiological, and flow-related risk factors for growth of untreated, unruptured intracranial aneurysms. Stroke 2015, 46(1): 42-48.

DOI Google Scholar

[4]

Greving JP, Wermer MJH, Brown RD Jr, Morita A, Juvela S, Yonekura M, Ishibashi T, Torner JC, Nakayama T, Rinkel GJE, Algra A. Development of the PHASES score for prediction of risk of rupture of intracranial aneurysms: A pooled analysis of six prospective cohort studies. Lancet Neurol 2014, 13(1): 59-66.

DOI Google Scholar

[5]

Ujiie H, Tamano Y, Sasaki K, Hori T. Is the aspect ratio a reliable index for predicting the rupture of a saccular aneurysm? Neurosurgery 2001, 48(3): 495-502.

DOI Google Scholar

[6]

Zanaty M, Chalouhi N, Tjoumakaris SI, Fernando GL, Rosenwasser RH, Jabbour PM. Aneurysm geometry in predicting the risk of rupture. A review of the literature. Neurol Res 2014, 36(4): 308-313.

DOI Google Scholar

[7]

San Millán Ruíz D, Yilmaz H, Dehdashti AR, Alimenti A, de Tribolet N, Rüfenacht DA. The perianeurysmal environment: Influence on saccular aneurysm shape and rupture. AJNR Am J Neuroradiol 2006, 27(3): 504-512.

Google Scholar

[8]

Golshani K, Ferrell A, Zomorodi A, Smith TP, Britz GW. A review of the management of posterior communicating artery aneurysms in the modern era. Surg Neurol Int 2010, 1: 88.

DOI Google Scholar

[9]

Wiebers DO, Whisnant JP, Huston J 3rd, Meissner I, Brown RD Jr, Piepgras DG, Forbes GS, Thielen K, Nichols D, O'Fallon WM, Peacock J, Jaeger L, Kassell NF, Kongable-Beckman GL, Torner JC; International Study of Unruptured Intracranial Aneurysms gators. Unruptured intracranial aneurysms: Natural history, clinical outcome, and risks of surgical and endovascular treatment. Lancet 2003, 362(9378): 103-110.

DOI Google Scholar

[10]

Dhar S, Tremmel M, Mocco J, Kim M, Yamamoto J, Siddiqui AH, Hopkins LN, Meng H. Morphology parameters for intracranial aneurysm rupture risk assessment. Neurosurgery 2008, 63(2): 185-196.

DOI Google Scholar

[11]

Cebral JR, Mut F, Weir J, Putman C. Quantitative characterization of the hemodynamic environment in ruptured and unruptured brain aneurysms. AJNR Am J Neuroradiol 2011, 32(1): 145-151.

DOI Google Scholar

[12]

Xiang JP, Natarajan SK, Tremmel M, Ma D, Mocco J, Hopkins LN, Siddiqui AH, Levy EI, Meng H. Hemodynamic-morphologic discriminants for intracranial aneurysm rupture. Stroke 2011, 42(1): 144-152.

DOI Google Scholar

[13]

Miura Y, Ishida F, Umeda Y, Tanemura H, Suzuki H, Matsushima S, Shimosaka S, Taki W. Low wall shear stress is independently associated with the rupture status of middle cerebral artery aneurysms. Stroke 2013, 44(2): 519-521.

DOI Google Scholar

[14]

Matsukawa H, Fujii M, Akaike G, Uemura A, Takahashi O, Niimi Y, Shinoda M. Morphological and clinical risk factors for posterior communicating artery aneurysm rupture. J Neurosurg 2014, 120(1): 104-110.

DOI Google Scholar

[15]

Vlak MHM, Algra A, Brandenburg R, Rinkel GJE. Prevalence of unruptured intracranial aneurysms, with emphasis on sex, age, comorbidity, country, and time period: A systematic review and meta-analysis. Lancet Neurol 2011, 10(7): 626-636.

DOI Google Scholar

[16]

Forget TR Jr, Benitez R, Veznedaroglu E, Sharan A, Mitchell W, Silva M, Rosenwasser RH. A review of size and location of ruptured intracranial aneurysms. Neurosurgery 2001, 49(6): 1322-1325.

DOI Google Scholar

[17]

Baharoglu MI, Schirmer CM, Hoit DA, Gao BL, Malek AM. Aneurysm inflow-angle as a discriminant for rupture in sidewall cerebral aneurysms: Morphometric and computational fluid dynamic analysis. Stroke 2010, 41(7): 1423-1430.

DOI Google Scholar

[18]

Tykocki T, Nauman P, Dow enko A. Morphometric predictors of posterior circulation aneurysms risk rupture. Neurol Res 2014, 36(8): 733-738.

DOI Google Scholar

About this article

Publication history

Acknowledgements

Rights and permissions

Publication history

Received: 03 August 2015

Revised: 18 September 2015

Accepted: 25 September 2015

Published: 01 December 2015

Issue date: December 2015

Copyright

Acknowledgements

This work was supported by the Key Project of Shanghai Science and Technology Committee (No. 13411950300), the National Natural Science Foundation of China (No. 81301004), the Key Project of Shanghai Municipal Health Bureau (No. 2013ZYJB007) and the 1255 Project of Changhai Hospital (No. CH125550400). We gratefully acknowledge the Shanghai Supercomputer Center for providing the mathematical soft wares that were used in this study.

Rights and permissions

This article is published with open access at www.TNCjournal.com