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Review Article | Publishing Language: Chinese | Open Access

Research progress on basic fibroblast growth factor in promoting periodontal tissue regeneration

Peipei ZHANG, Hongyan LI, Yue TIAN, Huishan CHEN, Hongbing LIN, Yuqin SHEN( )
Department of Endodontics, School and Hospital of Periodontology, Jilin University, Changchun 130021, China
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Abstract

Basic fibroblast growth factor (bFGF) exhibits superior biological functions by improving periodontal inflammation, promoting the migration and proliferation of periodontal-related stem cells, promoting the formation of blood vessels and periodontal ligament-like tissue, and regulating the formation of bone/cementum. It plays an important role in tooth development, repair and regeneration. bFGF can be combined with seed cells and scaffold materials for periodontal tissue regeneration, which has been verified in a number of experimental studies. However, the application of bFGF alone as a drug in clinical treatment requires further research.

Keywords

basic fibroblast growth factorinflammation controlmigrationproliferationangiogenesisperiodontal ligament-like tissueosteogenesis/cementumperiodontal tissue regenerationperiodontal disease
CLC number: R78 Document code: A Article ID: 2096-1456(2022)10-0757-04

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Journal of Prevention and Treatment for Stomatological Diseases
Volume 30 Issue 10,
October 2022
Pages 757-760
DOI: 10.12016/j.issn.2096-1456.2022.10.012

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Cite this article:
ZHANG P, LI H, TIAN Y, et al. Research progress on basic fibroblast growth factor in promoting periodontal tissue regeneration. Journal of Prevention and Treatment for Stomatological Diseases, 2022, 30(10): 757-760. https://doi.org/10.12016/j.issn.2096-1456.2022.10.012

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Received: 16 August 2021
Revised: 15 October 2021
Published: 20 October 2022
© 2022 by Editorial Department of Journal of Prevention and Treatment for Stomatological Diseases

This article is licensed under a Creative Commons Attribution 4.0 International License.