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Clinical Study | Publishing Language: Chinese | Open Access

Adverse drug reactions induced by hydroxychloroquine in the treatment of oral lichen planus: a report of 13 cases

Yao LIN, Jing HUANG, Xiaojuan XUE, Huan ZHANG, Bin FENG( )
State Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shaanxi Engineering Research Center for Dental Materials and Advanced Manufacture, Department of Pharmacy, School of Stomatology, the Fourth Military Medical University, Xi'an 710032, China
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Abstract

Objective

To analyze the adverse drug reaction（ADR）reports of hydroxychloroquine for clinical medication safety.

Methods

The ADR reports of hydroxychloroquine between May 2019 and May 2021 were analyzed. Age, reasons for drug use, time of ADR, combined drug use, and ADR outcomes were statistically analyzed.

Results

No severe ADR was reported. Patients over 60 years old accounted for 53.85% of the total cases, and the time of ADR appearance was significantly earlier among those under 60 years old. A total of 61.54% of ADRs were involved in multiple organs, and optic neurotoxicity was reported in 46.15% of cases.

Conclusion

In the treatment of oral lichen planus with hydroxychloroquine, adverse drug reactions should be monitored, and increased attention should be given to patients over 60 years old to ensure the safety of this medication.

Keywords

hydroxychloroquineoral mucosal diseaseadverse-drug reactionoptic neurotoxicityvision screeningcardiotoxicitymedication safetypackage inserts of drug
CLC number: R78 Document code: A Article ID: 2096-1456(2022)05-0350-05

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Journal of Prevention and Treatment for Stomatological Diseases
Volume 30 Issue 5,
May 2022
Pages 350-354
DOI: 10.12016/j.issn.2096-1456.2022.05.007

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LIN Y, HUANG J, XUE X, et al. Adverse drug reactions induced by hydroxychloroquine in the treatment of oral lichen planus: a report of 13 cases. Journal of Prevention and Treatment for Stomatological Diseases, 2022, 30(5): 350-354. https://doi.org/10.12016/j.issn.2096-1456.2022.05.007

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Received: 05 August 2021
Revised: 07 November 2021
Published: 20 May 2022
© 2022 by Editorial Department of Journal of Prevention and Treatment for Stomatological Diseases

This article is licensed under a Creative Commons Attribution 4.0 International License.