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Case Report | Open Access

The efficacy of transcutaneous auricular vagus nerve stimulation for patients with mild cognitive impairment and depressive symptoms: A case report and fMRI study

Chunlei Guoa,1, Jifei Sunb,1, Yue Mac, Shanshan Gaoa, Tianjiao Xua, Qingyan Chena, Lei Zhanga, Jiudong Caoa, Guolei Zhanga, Yang Honga, Hua Yand, Ge Yangd( ), Jiliang Fanga( )
Department of Radiology, Guang'anmen Hospital of China Academy of Chinese Medical Sciences, Beijing 100053, China
Department of Neurology, Shunyi Hospital of Beijing Hospital of TCM, Beijing 101300, China
Department of Traditional Chinese Medine, Beijing Children's Hospital, Capital University, National Center for Children's Health, Beijing 100045, China
Department of Geriatrics, Guang'anmen Hospital of China Academy of Chinese Medical Sciences, Beijing 100053, China

1 Chunlei Guo and Jifei Sun share first authorship.

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Abstract

This case report details a patient diagnosed with mild cognitive impairment concurrently exhibiting depressive symptoms and undergoing 24 weeks of transcutaneous vagus nerve stimulation therapy. After the 24-week treatment, the patient demonstrated notable improvement in both cognitive function and mood. Simultaneously, significant alterations were observed in the patient's temporal pole and medial orbitofrontal gyrus, regions associated with cognition and emotion. Furthermore, the patient continued to maintain a favorable status throughout the follow-up period. Therefore, transcutaneous vagus nerve stimulation may be a potential treatment for patients with mild cognitive impairment and depressive symptoms.

Keywords

Mild cognitive impairmentDepressive symptomsTranscutaneous auricular vagus nerve stimulationfMRI

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Journal of Neurorestoratology
Volume 13 Issue 3,
June 2025
DOI: 10.1016/j.jnrt.2025.100202
Cite this article:
Guo C, Sun J, Ma Y, et al. The efficacy of transcutaneous auricular vagus nerve stimulation for patients with mild cognitive impairment and depressive symptoms: A case report and fMRI study. Journal of Neurorestoratology, 2025, 13(3). https://doi.org/10.1016/j.jnrt.2025.100202

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Received: 23 October 2024
Revised: 26 January 2025
Accepted: 16 February 2025
Published: 01 June 2025
© 2025 The Author(s).

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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