AI Chat Paper
Note: Please note that the following content is generated by AMiner AI. SciOpen does not take any responsibility related to this content.
{{lang === 'zh_CN' ? '文章概述' : 'Summary'}}
{{lang === 'en_US' ? '中' : 'Eng'}}
Chat more with AI
Powered by AMiner. Clicking this button will take you away from SciOpen.
Home Journal of Neurorestoratology Article
Article Link
Cite
EndNote(RIS) BibTeX
Collect
Submit Manuscript
Show Outline
Outline
Show full outline
Hide outline
Outline
Show full outline
Hide outline
Editorial | Open Access

Neuroinflammation and neurorestoration following stroke: Molecular mechanisms and therapeutic approaches

Liang Caoa,b, Yi Zhangc, Wenjun Pid, Voon Wee Yonge( ), Mengzhou Xuea,b( )
Department of Cerebrovascular Diseases, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou 450014, Henan, China
Henan International Joint Laboratory of Intracerebral Hemorrhage and Brain Injury, Zhengzhou 450014, Henan, China
Shunyi Maternal and Children's Hospital of Beijing Children's Hospital, Beijing 101300, China
Department of Traumatic Orthopedics, The Affiliated Hospital of Guizhou Medical University, Guiyang 550004, Guizhou, China
Hotchkiss Brain Institute and Department of Clinical Neurosciences, University of Calgary, Calgary T2N 4N1, AB, Canada
Show Author Information

References

1

Shi ZY, Mao LL, Chen SN, et al. Reversing persistent PTEN activation after traumatic brain injury fuels long-term axonal regeneration via Akt/mTORC1 signaling cascade. Adv Sci. 2025;12(6):e2410136. https://doi.org/10.1002/advs.202410136.
Crossref Google Scholar
2

Yu YP, Zheng YL, Dong X, et al. Efficacy and safety of tirofiban in patients with acute ischemic stroke without large-vessel occlusion and not receiving intravenous thrombolysis: a randomized controlled open-label trial. J Neurorestoratol. 2022;10(4):100026. https://doi.org/10.1016/j.jnrt.2022.100026.
Crossref Google Scholar
3

Candelario-Jalil E, Dijkhuizen RM, Magnus T. Neuroinflammation, stroke, blood-brain barrier dysfunction, and imaging modalities. Stroke. 2022;53(5):1473–1486. https://doi.org/10.1161/STROKEAHA.122.036946.
Crossref Google Scholar
4

Iadecola C. The neurovascular unit coming of age: a journey through neurovascular coupling in health and disease. Neuron. 2017;96(1):17–42. https://doi.org/10.1016/j.neuron.2017.07.030.
Crossref Google Scholar
5

Xue MZ, Wee Yong V. Neuroinflammation in intracerebral haemorrhage: immunotherapies with potential for translation. Lancet Neurol. 2020;19(12):1023–1032. https://doi.org/10.1016/S1474-4422(20)30364-1.
Crossref Google Scholar
6

Tang XY, Wu L, Zhu JH, et al. GABAergic neurons differentiated from BDNF- and Dlx2-modified neural stem cells restore disrupted neural circuits in brainstem stroke. Stem Cell Res Ther. 2023;14(1):170. https://doi.org/10.1186/s13287-023-03378-5.
Crossref Google Scholar
7

Linnerbauer M, Rothhammer V. Protective functions of reactive astrocytes following central nervous system insult. Front Immunol. 2020;11:573256. https://doi.org/10.3389/fimmu.2020.573256.
Crossref Google Scholar
8

Hoeffel G, Debroas G, Roger A, et al. Sensory neuron-derived TAFA4 promotes macrophage tissue repair functions. Nature. 2021;594(7861):94–99. https://doi.org/10.1038/s41586-021-03563-7.
Crossref Google Scholar
9

Wang SJ, He QY, Qu Y, et al. Emerging strategies for nerve repair and regeneration in ischemic stroke: neural stem cell therapy. Neural Regen Res. 2024;19(11):2430–2443. https://doi.org/10.4103/1673-5374.391313.
Crossref Google Scholar
10

Kuriakose D, Xiao ZC. Pathophysiology and treatment of stroke: present status and future perspectives. Int J Mol Sci. 2020;21(20):7609. https://doi.org/10.3390/ijms21207609.
Crossref Google Scholar
Journal of Neurorestoratology
Volume 13 Issue 3,
June 2025
DOI: 10.1016/j.jnrt.2025.100201
Cite this article:
Cao L, Zhang Y, Pi W, et al. Neuroinflammation and neurorestoration following stroke: Molecular mechanisms and therapeutic approaches. Journal of Neurorestoratology, 2025, 13(3). https://doi.org/10.1016/j.jnrt.2025.100201

60

Views

5

Crossref

3

Web of Science

4

Scopus

Altmetrics
Received: 19 January 2025
Published: 01 June 2025
© 2025 The Author(s).

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Return