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Short Communication | Open Access

Analysis of causal relationship between immune cells and intracranial aneurysm: A mendelian randomization study

Yang Zhanga,b,1, Sifei Wangc,1, Yiming Huanga,b,1, Miaowen Jiangd, Baoying Songa,b, Di Wub, Ming Weic,d( ), Ming Lib( ), Xunming Jib,d,e( )
Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China
China–America Institute of Neurology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China
Department of Neurosurgery, Tianjin Huanhu Hospital, Tianjin 300000, China
Beijing Institute for Brain Disorders, Capital Medical University, Beijing 100069, China
Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing 100053, China

1 These authors contributed equally to this work.

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Abstract

Background

Immune cells have been detected in intracranial aneurysms (IAs). However, the causal effect of immune cell phenotypes on IAs remains unclear and difficult to comprehensively analyze.

Methods

Instrumental variables for 731 immunophenotypes were extracted from publicly available genetic databases. The influence of these immune cell traits on IAs was evaluated using the Mendelian randomization (MR) method. Five MR analysis methods, with inverse-variance-weighted as the main method, along with a comprehensive sensitivity analysis, were used to determine reliability of the results. Multivariable MR analysis was performed to correct for interactions between different immune cell phenotypes.

Results

Overall, 27 immune cell traits exhibited significant causal effects on IAs. Among them, 13 immunophenotypes increased the risk of IA progression. Conversely, 14 immune cell characteristics might protect against IAs. Following false discovery rate correction, two hazardous and three protective immunophenotypes remained significant. Moreover, multivariate MR analysis showed that only naive CD4− CD8− T cells %T cells remained causally associated with a risk of IA, while CD19 on IgD+ CD38− naive B cells inhibited development of IAs.

Conclusions

Our study shows that immune cell traits and IAs are causally correlated, providing a new theoretical framework for understanding immune-IA crosstalk.

Keywords

Immune cellIntracranial aneurysmMendelian randomization studySingle nucleotide polymorphismCausal relationship

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Journal of Neurorestoratology
Volume 13 Issue 1,
February 2025
DOI: 10.1016/j.jnrt.2024.100168

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Cite this article:
Zhang Y, Wang S, Huang Y, et al. Analysis of causal relationship between immune cells and intracranial aneurysm: A mendelian randomization study. Journal of Neurorestoratology, 2025, 13(1). https://doi.org/10.1016/j.jnrt.2024.100168

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Received: 26 June 2024
Revised: 24 August 2024
Accepted: 12 October 2024
Published: 01 February 2025
© 2024 The Authors.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).