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Practice Guidelines | Open Access

Guideline of clinical neurorestorative treatment for brain trauma (2022 China version)

Xiaofeng Yanga( )Lin ChenbJiangbo PucYusheng LidJinquan CaieLukui ChenfShiqing FenggJianghong HehYunliang WangiSai ZhangjShixiang ChengjkHongyun Huangl( )
The First Affiliated Hospital Zhejiang University School of Medicine, Hangzhou 310003, Zhejiang, China
Department of Neurosurgery, Dongzhimen Hospital, Beijing University of Traditional Chinese Medicine, Beijing 100700, China
Institute of Biomedical Engineering, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300192, China
First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan, China
Department of Neurosurgery, The Second Affiliated Hospital of Harbin Medical University, Harbin 150081, Helongjiang, China
Department of Neurosurgery, Neuroscience Center, Integrated Hospital of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510310, Guangdong, China
Department of Orthopedics, Tianjin Medical University General Hospital, Tianjin 300052, China
Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China
Department of Neurology, The 960 Hospital of Joint Support Force of PLA, Zibo 255300, Shandong, China
Xincheng Hospital of Tianjin University, Tianjin 300467, China
Healthina Academy of Cellular Intelligence Manufacturing & Neurotrauma Repair of Tianjin Economic-Technological Development Area (ACMN-TEDA), Tianjin 300467, China
Beijing Hongtianji Neuroscience Academy, Beijing 100143, China
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Brain trauma or traumatic brain injury (TBI) is one of the leading causes of death and disability worldwide. Along with the conventional therapeutic strategies, neurorestorative treatments for TBI have been developed in recent decades. However, missing standards and guidelines has become a growing issue both in clinical practice and fundamental research. Consequently, the Chinese Association of Neurorestoratology (Preparatory; CANR) and the China Committee of International Association of Neurorestoratology (IANR-China Committee) have reached a consensus to form and approve the Guideline of Clinical Neurorestorative Treatment for Brain Trauma. This guideline addresses the common issues in the evaluation and therapies of TBI patients within the scope of Neurorestoratology, offers recommendations based on state-of-art clinical evidences, and covers cell therapies, neural stimulation therapies, and pharmaceutical therapies. Hopefully, this guideline may provide references to clinical professionals during diagnosis and treatment, maximizing the neurorestorative therapeutic efficacy.

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Journal of Neurorestoratology
Article number: 100005
Cite this article:
Yang X, Chen L, Pu J, et al. Guideline of clinical neurorestorative treatment for brain trauma (2022 China version). Journal of Neurorestoratology, 2022, 10(2): 100005.






Web of Science




Received: 15 November 2021
Revised: 25 January 2022
Accepted: 13 February 2022
Published: 14 June 2022
© 2022 The Authors. Published by Elsevier Ltd on behalf of Tsinghua University Press.

This is an open access article under the CC BY-NC-ND license (