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In light of the ongoing COVID-19 pandemic, the unexpected outbreak and worldwide spread of monkeypox has gained global attention. As of June 22, 2022, there were 3340 confirmed cases of monkeypox globally, which is the largest and most widespread monkeypox epidemic outside Africa. Monkeypox virus (MPXV) is transmitted from human-to-human through direct contact with infectious skin or mucosal skin lesions, respiratory droplets, or indirect contact with contaminated objects or materials, as well as mother-to-child vertical transmission. It is also possibly sexually transmitted through semen/vaginal fluid, and the possibility of community transmission cannot be ruled out. Monkeypox is a viral zoonotic disease caused by MPXV, which is an enveloped, linear, double-stranded DNA virus belonging to the Orthopoxvirus genus, of the Chordopoxvirinae subfamily, within the Poxviridae family. Monkeypox is usually a self-limiting infection, with symptoms lasting 2–4 weeks, and has a fatality rate that has historically fluctuated from 0% to 11%. Symptoms of monkeypox include intense headaches, fever, lesions, and lymphadenopathy. Although there is no specific treatment or vaccine for MPXV infection, antiviral drugs and vaccines for smallpox have been approved for use in several countries in response to the monkeypox outbreak. Before the virus can be allowed to establish efficient person-to-person transmission, rapid action must be taken to contain the local spread and, by extension, the multi-country outbreak of monkeypox.
In light of the ongoing COVID-19 pandemic, the unexpected outbreak and worldwide spread of monkeypox has gained global attention. As of June 22, 2022, there were 3340 confirmed cases of monkeypox globally, which is the largest and most widespread monkeypox epidemic outside Africa. Monkeypox virus (MPXV) is transmitted from human-to-human through direct contact with infectious skin or mucosal skin lesions, respiratory droplets, or indirect contact with contaminated objects or materials, as well as mother-to-child vertical transmission. It is also possibly sexually transmitted through semen/vaginal fluid, and the possibility of community transmission cannot be ruled out. Monkeypox is a viral zoonotic disease caused by MPXV, which is an enveloped, linear, double-stranded DNA virus belonging to the Orthopoxvirus genus, of the Chordopoxvirinae subfamily, within the Poxviridae family. Monkeypox is usually a self-limiting infection, with symptoms lasting 2–4 weeks, and has a fatality rate that has historically fluctuated from 0% to 11%. Symptoms of monkeypox include intense headaches, fever, lesions, and lymphadenopathy. Although there is no specific treatment or vaccine for MPXV infection, antiviral drugs and vaccines for smallpox have been approved for use in several countries in response to the monkeypox outbreak. Before the virus can be allowed to establish efficient person-to-person transmission, rapid action must be taken to contain the local spread and, by extension, the multi-country outbreak of monkeypox.
J Isidro, V Borges, M Pinto, et al., Phylogenomic characterization and signs of microevolution in the 2022 multi-country outbreak of monkeypox virus, Nat Med (2022), doi: 10.1038/s41591-022-01907-y.
SK Saxena, S Ansari, VK Maurya, et al., Re-emerging human monkeypox: a major public-health debacle, J Med Virol (2022), doi: 10.1002/jmv.27902.
S Kumar, G Subramaniam, K. Karuppanan, Human monkeypox outbreak in 2022, J Med Virol (2022), doi: 10.1002/jmv.27894.
E Alakunle, U Moens, G Nchinda, et al., Monkeypox virus in Nigeria: infection biology, epidemiology, and evolution, Viruses 12 (11) (2020), doi: 10.3390/v12111257.
CT Cho, HA. Wenner, Monkeypox virus, Bacteriol Rev 37 (1) (1973) 1–18, doi: 10.1128/br.37.1.1-18.1973.
SN Shchelkunov, AV Totmenin, PF Safronov, et al., Analysis of the monkeypox virus genome, Virology 297 (2) (2002) 172–194, doi: 10.1006/viro.2002.1446.
JR Kugelman, SC Johnston, PM Mulembakani, et al., Genomic variability of monkeypox virus among humans, Democratic Republic of the Congo, Emerg Infect Dis 20 (2) (2014) 232–239, doi: 10.3201/eid2002.130118.
N Chen, G Li, MK Liszewski, et al., Virulence differences between monkeypox virus isolates from West Africa and the Congo basin, Virology 340 (1) (2005) 46–63, doi: 10.1016/j.virol.2005.05.030.
AM McCollum, IK. Damon, Human monkeypox, Clin Infect Dis 58 (2) (2014) 260–267, doi: 10.1093/cid/cit703.
E Petersen, A Kantele, M Koopmans, et al., Human monkeypox: epidemiologic and clinical characteristics, diagnosis, and prevention, Infect Dis Clin North Am 33 (4) (2019) 1027–1043, doi: 10.1016/j.idc.2019.03.001.
B Cabanillas, R Valdelvira, CA. Akdis, Monkeypox outbreak in Europe, UK, North America, and Australia: a changing trend of a zoonotic disease, Allergy (2022), doi: 10.1111/all.15393.
A Yinka-Ogunleye, O Aruna, M Dalhat, et al., Outbreak of human monkeypox in Nigeria in 2017-18: a clinical and epidemiological report, Lancet Infect Dis 19 (8) (2019) 872–879, doi: 10.1016/S1473-3099(19)30294-4.
G Hobson, J Adamson, H Adler, et al., Family cluster of three cases of monkeypox imported from Nigeria to the United Kingdom, May 2021, Euro Surveill 26 (32) (2021), doi: 10.2807/1560-7917.ES.2021.26.32.2100745.
E. Harris, What to know about monkeypox, JAMA (2022), doi: 10.1001/jama.2022.9499.
MG Reynolds, JB Doty, AM McCollum, et al., Monkeypox re-emergence in Africa: a call to expand the concept and practice of one health, Expert Rev Anti Infect Ther 17 (2) (2019) 129–139, doi: 10.1080/14787210.2019.1567330.
KN Durski, AM McCollum, Y Nakazawa, et al., Emergence of monkeypox - West and Central Africa, 1970-2017, MMWR Morb Mortal Wkly Rep 67 (10) (2018) 306–310, doi: 10.15585/mmwr.mm6710a5.
Centers for Disease C, Prevention, Multistate outbreak of monkeypox–Illinois, Indiana, and Wisconsin, 2003, MMWR Morb Mortal Wkly Rep 52 (23) (2003) 537–540.
LD Nolen, L Osadebe, J Katomba, et al., Introduction of monkeypox into a Community and household: risk factors and zoonotic reservoirs in the Democratic Republic of the Congo, Am J Trop Med Hyg 93 (2) (2015) 410–415, doi: 10.4269/ajtmh.15-0168.
HK van Saene, CC Stoutenbeek, JK. Stoller, Selective decontamination of the digestive tract in the intensive care unit: current status and future prospects, Crit Care Med 20 (5) (1992) 691–703, doi: 10.1097/00003246-199205000-00024.
C Ihekweazu, A Yinka-Ogunleye, S Lule, et al., Importance of epidemiological research of monkeypox: is incidence increasing? Expert Rev Anti Infect Ther 18 (5) (2020) 389–392, doi: 10.1080/14787210.2020.1735361.
SN Shchelkunov, AV Totmenin, IV Babkin, et al., Human monkeypox and smallpox viruses: genomic comparison, FEBS Lett 509 (1) (2001) 66–70, doi: 10.1016/s0014-5793(01)03144-1.
R Vivancos, C Anderson, P Blomquist, et al., Community transmission of monkeypox in the United Kingdom, April to May 2022, Euro Surveill 27 (22) (2022), doi: 10.2807/1560-7917.ES.2022.27.22.2200422.
PY Nguyen, WS Ajisegiri, V Costantino, et al., Reemergence of human monkeypox and declining population immunity in the context of urbanization, Nigeria, 2017-2020, Emerg Infect Dis 27 (4) (2021), doi: 10.3201/eid2704.203569.
DK L'Vov, VV Zverev, AL Gintsburg, et al., [Smallpox is a dormant volcano], Vopr Virusol 53 (4) (2008) 4–8.
IV Babkin, IN Babkina, NV. Tikunova, An update of orthopoxvirus molecular evolution, Viruses 14 (2) (2022), doi: 10.3390/v14020388.
I Arita, R Gispen, SS Kalter, et al., Outbreaks of monkeypox and serological surveys in nonhuman primates, Bull World Health Organ 46 (5) (1972) 625–631.
ID Ladnyj, P Ziegler, E. Kima, A human infection caused by monkeypox virus in Basankusu Territory, Democratic Republic of the Congo, Bull World Health Organ 46 (5) (1972) 593–597.
EM Bunge, B Hoet, L Chen, et al., The changing epidemiology of human monkeypoxA potential threat? A systematic review, PLoS Negl Trop Dis 16 (2) (2022) e0010141, doi: 10.1371/journal.pntd.0010141.
DL Heymann, M Szczeniowski, K. Esteves, Re-emergence of monkeypox in Africa: a review of the past six years, Br Med Bull 54 (3) (1998) 693–702, doi: 10.1093/oxfordjournals.bmb.a011720.
AK Rao, J Schulte, TH Chen, et al., Monkeypox in a traveler returning from Nigeria - Dallas, Texas, July 2021, MMWR Morb Mortal Wkly Rep 71 (14) (2022) 509–516, doi: 10.15585/mmwr.mm7114a1.
V Costello, M Sowash, A Gaur, et al., Imported monkeypox from international traveler, Maryland, USA, 2021, Emerg Infect Dis 28 (5) (2022) 1002–1005, doi: 10.3201/eid2805.220292.
N Erez, H Achdout, E Milrot, et al., Diagnosis of imported monkeypox, Israel, 2018, Emerg Infect Dis 25 (5) (2019) 980–983, doi: 10.3201/eid2505.190076.
OT Ng, V Lee, K Marimuthu, et al., A case of imported monkeypox in Singapore, Lancet Infect Dis 19 (11) (2019) 1166, doi: 10.1016/S1473-3099(19)30537-7.
NP Manes, RD Estep, HM Mottaz, et al., Comparative proteomics of human monkeypox and vaccinia intracellular mature and extracellular enveloped virions, J Proteome Res 7 (3) (2008) 960–968, doi: 10.1021/pr070432+.
N Sklenovska, M. Van Ranst, Emergence of monkeypox as the most important orthopoxvirus infection in humans, Front Public Health 6 (2018) 241, doi: 10.3389/fpubh.2018.00241.
I Iizuka, M Saijo, T Shiota, et al., Loop-mediated isothermal amplification-based diagnostic assay for monkeypox virus infections, J Med Virol 81 (6) (2009) 1102–1108, doi: 10.1002/jmv.21494.
Y Li, H Zhao, K Wilkins, et al., Real-time PCR assays for the specific detection of monkeypox virus West African and Congo Basin strain DNA, J Virol Methods 169 (1) (2010) 223–227, doi: 10.1016/j.jviromet.2010.07.012.
L Vitiello, S Ilari, L Sansone, et al., Preventive measures against pandemics from the beginning of civilization to nowadays-how everything has remained the same over the millennia, J Clin Med 11 (7) (2022), doi: 10.3390/jcm11071960.
M Memariani, H. Memariani, Multinational monkeypox outbreak: what do we know and what should we do? Ir J Med Sci (2022), doi:10.1007/s11845-022-03052-4.
We apologize to any scientist whose excellent work could not be discussed because of space limitations.
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