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Rapid Communication | Open Access

ApoL1 risk allele accelerates high-fat diet-induced atherosclerosis in LDLR−/− hamsters

Yitong Xua,1Wenxi Zhanga,1Jiabao GuoaJinxuan ChenaGuolin MiaoaLianxin ZhangaYufei HanaJingxuan ChenaYing ZhaobXunde Xiana,c( )
Institute of Cardiovascular Sciences, State Key Laboratory of Vascular Homeostasis and Remodeling, School of Basic Medical Sciences, Peking University, Beijing 100191, China
Department of Urology, China-Japan Friendship Hospital, Beijing 100029, China
Beijing Key Laboratory of Cardiovascular Receptors Research, Peking University Third Hospital, Beijing 100191, China

1 These authors contributed equally to this work.

Peer review under responsibility of Chongqing Medical University.

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References

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Pays E, Radwanska M, Magez S. The pathogenesis of African trypanosomiasis. Annu Rev Pathol. 2023;18:19-45.

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Adeva-Andany MM, Funcasta-Calderón R, Fernández-Fernández C, Ameneiros-Rodríguez E, Vila-Altesor M, Castro-Quintela E. The metabolic effects of APOL1 in humans. Pflugers Arch. 2023;475(8):911-932.

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Yoshida T, Latt KZ, Heymann J, Kopp JB. Lessons from APOL1 animal models. Front Med. 2021;8:762901.

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Guo X, Gao M, Wang Y, et al. LDL receptor gene-ablated hamsters: a rodent model of familial hypercholesterolemia with dominant inheritance and diet-induced coronary atherosclerosis. EBioMedicine. 2018;27:214-224.

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Wu J, Raman A, Coffey NJ, et al. The key role of NLRP3 and STING in APOL1-associated podocytopathy. J Clin Invest. 2021;131(20):e136329.

Genes & Diseases
Article number: 101379
Cite this article:
Xu Y, Zhang W, Guo J, et al. ApoL1 risk allele accelerates high-fat diet-induced atherosclerosis in LDLR−/− hamsters. Genes & Diseases, 2025, 12(2): 101379. https://doi.org/10.1016/j.gendis.2024.101379

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Received: 17 April 2024
Published: 23 July 2024
© 2024 The Authors.

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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