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Rapid Communication | Open Access

Integrative analysis of the metabolomes and transcriptomes of Ebola virus-infected cells: Uncovering pathways related to hepatic apoptosis

Chenchen Liua,b,1Zengguo Caoa,1Cheng Pengc,1Fangxu LiaZixi ChendXinghai ZhangaXiaoying JiaaJinge Zhoua,bWenting Maoa,bEntao Lie,gGengfu Xiaoa( )Sandra Chiue,f,g( )
Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, Hubei 430071, China
University of Chinese Academy of Sciences, Beijing 100190, China
National Biosafety Laboratory, Chinese Academy of Sciences, Wuhan, Hubei 430020, China
Shenzhen Key Laboratory of Marine Bioresource and Eco-environmental Science, Shenzhen Engineering Laboratory for Marine Algal Biotechnology, Guangdong Provincial Key Laboratory for Plant Epigenetics, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen, Guangdong 518060, China
Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui 230026, China
Department of Laboratory Medicine, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui 230026, China
Key Laboratory of Anhui Province for Emerging and Reemerging Infectious Diseases, Hefei, Anhui 230026, China

Peer review under responsibility of Chongqing Medical University.

1 These authors contributed equally to this work.

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References

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Kuhn JH, Amarasinghe GK, Basler CF, et al. ICTV virus taxonomy profile: Filoviridae. J Gen Virol. 2019;100(6):911–912.

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Bradfute SB, Swanson PE, Smith MA, et al. Mechanisms and consequences of ebolavirus-induced lymphocyte apoptosis. J Immunol. 2010;184(1):327–335.

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da Costa KA, Niculescu MD, Craciunescu CN, Fischer LM, Zeisel SH. Choline deficiency increases lymphocyte apoptosis and DNA damage in humans. Am J Clin Nutr. 2006;84(1):88–94.

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Lupberger J, Croonenborghs T, Suarez AAR, et al. Combined analysis of metabolomes, proteomes, and transcriptomes of hepatitis C virus-infected cells and liver to identify pathways associated with disease development. Gastroenterology. 2019;157(2):537–551.e9.

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Mori K. Tripartite management of unfolded proteins in the endoplasmic reticulum. Cell. 2000;101(5):451–454.

Genes & Diseases
Article number: 101377
Cite this article:
Liu C, Cao Z, Peng C, et al. Integrative analysis of the metabolomes and transcriptomes of Ebola virus-infected cells: Uncovering pathways related to hepatic apoptosis. Genes & Diseases, 2025, 12(2): 101377. https://doi.org/10.1016/j.gendis.2024.101377

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Received: 07 March 2024
Published: 16 July 2024
© 2024 The Authors.

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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