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Rapid Communication | Open Access

Alternative splicing of immune-related genes identifies breast cancer subtypes with differential immune cell infiltration

Zhangxiang Zhaoa,1Yuquan Wangb,1Zixin JincHuiming HancBo ChencMingyue LiucKaidong LiucShuping ZhuangbHaihai Lianga,b( )Yunyan Guc( )
The Sino-Russian Medical Research Center of Jinan University, The Institute of Chronic Disease of Jinan University, The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong 510632, China
Department of Pharmacology (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education), College of Pharmacy, Harbin Medical University, Harbin, Heilongjiang 150081, China
Department of Systems Biology, College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Heilongjiang 150081, China

1 These authors contributed equally to this work.

Peer review under responsibility of Chongqing Medical University.

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References

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Shalek AK, Satija R, Adiconis X, et al. Single-cell transcriptomics reveals bimodality in expression and splicing in immune cells. Nature. 2013;498(7453):236–240.

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Blake D, Radens CM, Ferretti MB, Gazzara MR, Lynch KW. Alternative splicing of apoptosis genes promotes human T cell survival. Elife. 2022;11:e80953.

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Ru B, Wong CN, Tong Y, et al. TISIDB: an integrated repository portal for tumor-immune system interactions. Bioinformatics. 2019;35(20):4200–4202.

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Castro-Mondragon JA, Riudavets-Puig R, Rauluseviciute I, et al. JASPAR 2022:the 9th release of the open-access database of transcription factor binding profiles. Nucleic Acids Res. 2022;50(D1):D165–D173.

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Li J, Ballif BA, Powelka AM, Dai J, Gygi SP, Hsu VW. Phosphorylation of ACAP1 by Akt regulates the stimulation-dependent recycling of integrin beta1 to control cell migration. Dev Cell. 2005;9(5):663–673.

Genes & Diseases
Article number: 101349
Cite this article:
Zhao Z, Wang Y, Jin Z, et al. Alternative splicing of immune-related genes identifies breast cancer subtypes with differential immune cell infiltration. Genes & Diseases, 2025, 12(2): 101349. https://doi.org/10.1016/j.gendis.2024.101349

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Received: 24 December 2023
Published: 14 June 2024
© 2024 The Authors.

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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