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Rapid Communication | Open Access

Mutational single nucleotide polymorphism rs198389 and demethylation promoted natriuretic peptide B gene transcription in heart failure caused by dilated cardiomyopathy

Yulong Lia,1Mingzhi Shenb,1Ting Yangc,1Shui Yud,1Jianyuan YineLeiming Luof( )Yali Zhaoc( )Ping Pingg( )Shihui Fuf,h( )
Agency for Offices Administration of Central Military Commission, Beijing 100034, China
Department of General Practice, Hainan Hospital of Chinese People's Liberation Army General Hospital, Sanya, Hainan 572013, China
Central Laboratory, Hainan Hospital of Chinese People's Liberation Army General Hospital, Sanya, Hainan 572013, China
Dermatology Department, Hainan Hospital of Chinese People's Liberation Army General Hospital, Sanya, Hainan 572013, China
Department of Critical Care, Hainan Hospital of Chinese People's Liberation Army General Hospital, Sanya, Hainan 572013, China
Department of Geriatric Cardiology, Chinese People's Liberation Army General Hospital, Beijing 100853, China
General Station for Drug and Instrument Supervision and Control, Joint Logistic Support Force of Chinese People's Liberation Army, Beijing 100076, China
Department of Cardiology, Hainan Hospital of Chinese People's Liberation Army General Hospital, Hainan Geriatric Disease Clinical Medical Research Center, Hainan Branch of China Geriatric Disease Clinical Research Center, Sanya, Hainan 572013, China

1 These authors contributed equally to this work and shared the first authorship.

Peer review under responsibility of Chongqing Medical University.

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References

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Roger VL, Go AS, Lloyd-Jones DM, et al. Heart disease and stroke statistics–2011 update: a report from the American Heart Association. Circulation. 2011;123(4):e18-e209.

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Fu S, Ping P, Wang F, Luo L. Synthesis, secretion, function, metabolism and application of natriuretic peptides in heart failure. J Biol Eng. 2018;12(1):2.

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Lanfear DE. Genetic variation in the natriuretic peptide system and heart failure. Heart Fail Rev. 2010;15(3):219-228.

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Tiret L, Mallet C, Poirier O, et al. Lack of association between polymorphisms of eight candidate genes and idiopathic dilated cardiomyopathy. J Am Coll Cardiol. 2000;35(1):29-35.

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Thomson JP, Skene PJ, Selfridge J, et al. CpG islands influence chromatin structure via the CpG-binding protein Cfp1. Nature. 2010;464(7291):1082-1086.

Genes & Diseases
Article number: 101345
Cite this article:
Li Y, Shen M, Yang T, et al. Mutational single nucleotide polymorphism rs198389 and demethylation promoted natriuretic peptide B gene transcription in heart failure caused by dilated cardiomyopathy. Genes & Diseases, 2025, 12(2): 101345. https://doi.org/10.1016/j.gendis.2024.101345

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Received: 28 January 2023
Published: 31 May 2024
© 2024 The Authors.

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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