AI Chat Paper
Note: Please note that the following content is generated by AMiner AI. SciOpen does not take any responsibility related to this content.
{{lang === 'zh_CN' ? '文章概述' : 'Summary'}}
{{lang === 'en_US' ? '中' : 'Eng'}}
Chat more with AI
Powered by AMiner. Clicking this button will take you away from SciOpen.
Home Genes & Diseases Article
PDF (861.2 KB)
Cite
EndNote(RIS) BibTeX
Collect
Submit Manuscript AI Chat Paper
Show Outline
Outline
Show full outline
Hide outline
Outline
Show full outline
Hide outline
Rapid Communication | Open Access

Human amniotic epithelial cells alleviate ischemia-reperfusion injury of steatotic livers through mediating PAK1/AMPK-dependent autophagy

Xun Qiua,b,1, Hanzhi Xua,b,1, Yawen Tana,b, Jinying Lic,d, Zhoucheng Wanga,b, Zhengxing Lianb, Xuyong Weia,b, Luyang Yuc,d, Kai Wange( ), Xiao Xuf,g ( )
Zhejiang University School of Medicine, Hangzhou, Zhejiang 310058, China
Key Laboratory of Integrated Oncology and Intelligent Medicine of Zhejiang Province, Hangzhou, Zhejiang 310006, China
Institute of Genetics and Regenerative Biology, College of Life Sciences, Hangzhou, Zhejiang 310058, China
Center for Stem Cell and Regenerative Medicine, Zhejiang University, Hangzhou, Zhejiang 310058, China
Department of Hepatobiliary & Pancreatic Surgery and Minimally Invasive Surgery, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital), Hangzhou Medical College, Hangzhou, Zhejiang 310014, China
School of Clinical Medicine, Hangzhou Medical College, Hangzhou, Zhejiang 310059, China
Institute of Translational Medicine, Zhejiang University, Hangzhou, Zhejiang 310000, China

Peer review under responsibility of Chongqing Medical University.

1 These authors contributed equally to this work.

Show Author Information

References

1

Gao F, Qiu X, Wang K, et al. Targeting the hepatic microenvironment to improve ischemia/reperfusion injury: new insights into the immune and metabolic compartments. Aging Dis. 2022;13(4):1196–1214.
Crossref Google Scholar
2

Wang B, Wang Y, Zhang J, et al. ROS-induced lipid peroxidation modulates cell death outcome: mechanisms behind apoptosis, autophagy, and ferroptosis. Arch Toxicol. 2023;97(6):1439–1451.
Crossref Google Scholar
3

Zhang Q, Lai D. Application of human amniotic epithelial cells in regenerative medicine: a systematic review. Stem Cell Res Ther. 2020;11(1):439.
Crossref Google Scholar
4

Qiu X, Xu H, Wang K, Gao F, Xu X, He H. P-21 activated kinases in liver disorders. Cancers. 2023;15(2):551.
Crossref Google Scholar
5

Mao Y, Han CY, Hao L, et al. p21-activated kinase 4 inhibition protects against liver ischemia/reperfusion injury: role of nuclear factor erythroid 2-related factor 2 phosphorylation. Hepatology. 2022;76(2):345–356.
Crossref Google Scholar
Genes & Diseases
Volume 12 Issue 2,
March 2025
Article number: 101343
DOI: 10.1016/j.gendis.2024.101343
Cite this article:
Qiu X, Xu H, Tan Y, et al. Human amniotic epithelial cells alleviate ischemia-reperfusion injury of steatotic livers through mediating PAK1/AMPK-dependent autophagy. Genes & Diseases, 2025, 12(2): 101343. https://doi.org/10.1016/j.gendis.2024.101343

70

Views

1

Downloads

0

Crossref

0

Web of Science

0

Scopus

0

CSCD

Altmetrics
Received: 12 October 2023
Published: 29 May 2024
© 2024 The Authors.

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Return