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Rapid Communication | Open Access

Identification of hypermethylated CpG sites mapped to LIFR as specific diagnostic biomarkers of colon cancer

Ruizhi Chang2Ganxun Li2Guan-nan Jin1( )Bixiang Zhang( )Ze-yang Ding( )
Department of Surgery and Hubei Key Laboratory of Hepatic-Pancreatic-Biliary Diseases, National Medical Center for Major Public Health Events, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China

Peer review under responsibility of Chongqing Medical University.

2 These authors contributed equally to this work.

1 Present address: Department of Internal Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430077, China.

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References

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Ferlay J, Colombet M, Soerjomataram I, et al. Cancer statistics for the year 2020:an overview. Int J Cancer. 2021;149(4):778–789.

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Zhang J, Huang K. Pan-cancer analysis of frequent DNA co-methylation patterns reveals consistent epigenetic landscape changes in multiple cancers. BMC Genom. 2017;18(Suppl 1):1045.

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Hao X, Luo H, Krawczyk M, et al. DNA methylation markers for diagnosis and prognosis of common cancers. Proc Natl Acad Sci USA. 2017;114(28):7414–7419.

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Naumov VA, Generozov EV, Zaharjevskaya NB, et al. Genome-scale analysis of DNA methylation in colorectal cancer using Infinium HumanMethylation450 BeadChips. Epigenetics. 2013;8(9):921–934.

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Varadhachary GR, Raber MN, Matamoros A, Abbruzzese JL. Carcinoma of unknown primary with a colon-cancer profile-changing paradigm and emerging definitions. Lancet Oncol. 2008;9(6):596–599.

Genes & Diseases
Article number: 101334
Cite this article:
Chang R, Li G, Jin G-n, et al. Identification of hypermethylated CpG sites mapped to LIFR as specific diagnostic biomarkers of colon cancer. Genes & Diseases, 2025, 12(2): 101334. https://doi.org/10.1016/j.gendis.2024.101334

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Received: 02 December 2023
Published: 19 May 2024
© 2024 The Authors.

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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